| Title |
Association between cannabis use and methadone maintenance treatment outcomes: an investigation into sex differences
|
|---|---|
| Published in |
Biology of Sex Differences, March 2017
|
| DOI | 10.1186/s13293-017-0130-1 |
| Pubmed ID | |
| Authors |
Laura Zielinski, Meha Bhatt, Nitika Sanger, Carolyn Plater, Andrew Worster, Michael Varenbut, Jeff Daiter, Guillaume Pare, David C. Marsh, Dipika Desai, James MacKillop, Meir Steiner, Stephanie McDermid Vaz, Lehana Thabane, Zainab Samaan |
| Abstract |
Cannabis will soon become legalized in Canada, and it is currently unclear how this will impact public health. Methadone maintenance treatment (MMT) is the most common pharmacological treatment for opioid use disorder (OUD), and despite its documented effectiveness, a large number of patients respond poorly and experience relapse to illicit opioids. Some studies implicate cannabis use as a risk factor for poor MMT response. Although it is well established that substance-use behaviors differ by sex, few of these studies have considered sex as a potential moderator. The current study aims to investigate sex differences in the association between cannabis use and illicit opioid use in a cohort of MMT patients. This multicentre study recruited participants on MMT for OUD from Canadian Addiction Treatment Centre sites in Ontario, Canada. Sex differences in the association between any cannabis use and illicit opioid use were investigated using multivariable logistic regression. A secondary analysis was conducted to investigate the association with heaviness of cannabis use. The study included 414 men and 363 women with OUD receiving MMT. Cannabis use was significantly associated with illicit opioid use in women only (OR = 1.82, 95% CI 1.18, 2.82, p = 0.007). Heaviness of cannabis use was not associated with illicit opioid use in men or women. This is the largest study to date examining the association between cannabis use and illicit opioid use. Cannabis use may be a sex-specific predictor of poor response to MMT, such that women are more likely to use illicit opioids if they also use cannabis during treatment. Women may show improved treatment outcomes if cannabis use is addressed during MMT. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 43% |
| United Kingdom | 1 | 7% |
| Australia | 1 | 7% |
| Argentina | 1 | 7% |
| Unknown | 5 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 79% |
| Practitioners (doctors, other healthcare professionals) | 2 | 14% |
| Scientists | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 108 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 19 | 18% |
| Student > Bachelor | 17 | 16% |
| Researcher | 12 | 11% |
| Student > Ph. D. Student | 11 | 10% |
| Professor > Associate Professor | 7 | 6% |
| Other | 17 | 16% |
| Unknown | 25 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 31 | 29% |
| Neuroscience | 7 | 6% |
| Psychology | 5 | 5% |
| Nursing and Health Professions | 5 | 5% |
| Biochemistry, Genetics and Molecular Biology | 4 | 4% |
| Other | 19 | 18% |
| Unknown | 37 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 39. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2022.
All research outputs
#1,005,519
of 24,518,979 outputs
Outputs from Biology of Sex Differences
#43
of 533 outputs
Outputs of similar age
#20,837
of 313,094 outputs
Outputs of similar age from Biology of Sex Differences
#2
of 8 outputs
Altmetric has tracked 24,518,979 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 533 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.5. This one has done particularly well, scoring higher than 92% of its peers.
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