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Mendeley readers
Attention Score in Context
| Title |
Nicotine effects on attentional reorienting in mid-age adults, and interactions with apolipoprotein E status
|
|---|---|
| Published in |
Journal of Psychopharmacology, August 2013
|
| DOI | 10.1177/0269881113499828 |
| Pubmed ID | |
| Authors |
Simon Evans, Nicholas G Dowell, Naji Tabet, Paul S Tofts, Sarah L King, Marcus Gray, Jennifer M Rusted |
| Abstract |
Nicotine has been shown to speed attentional reorienting in cued target detection tasks, and work in young adults suggest that individuals carrying the apolipoprotein E (APOE) e4 allele might show greater sensitivity to the cognitive effects of nicotine. The APOE e4 allele is associated with increased risk of Alzheimer's disease (AD), and increased sensitivity to nicotine might reflect early cholinergic differences that relate to an enhanced risk of AD. The aim of this study was to investigate effects of nicotine and APOE on attentional reorienting in mid-age participants. APOE e4 (e4+) were compared to non-APOE e4 (e4-) carriers, and functional magnetic resonance imaging (fMRI) data acquired. Neural data showed that nicotine effects, and the network involved in reorienting, was consistent with studies in young adults. Nicotine improved attentional reorienting at the trend level. Although there were no behavioural effects of genotype, genotype effects were present neurally: e4+ showed decreased extrastriate activation, and enhanced effects of nicotine on reorienting in right middle frontal regions. Drug by genotype interactions were present in hippocampal and anterior cingulate regions. These results are consistent with differential sensitivity to nicotine according to APOE status, possibly reflecting abnormal cholinergic function and accelerated cognitive ageing in mid-age e4+. |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 42 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 19% |
| Student > Ph. D. Student | 8 | 19% |
| Student > Master | 5 | 12% |
| Student > Doctoral Student | 3 | 7% |
| Student > Bachelor | 2 | 5% |
| Other | 3 | 7% |
| Unknown | 13 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 12 | 29% |
| Neuroscience | 6 | 14% |
| Agricultural and Biological Sciences | 6 | 14% |
| Medicine and Dentistry | 3 | 7% |
| Chemical Engineering | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 13 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2016.
All research outputs
#15,281,593
of 22,725,280 outputs
Outputs from Journal of Psychopharmacology
#1,409
of 1,930 outputs
Outputs of similar age
#122,444
of 198,428 outputs
Outputs of similar age from Journal of Psychopharmacology
#23
of 29 outputs
Altmetric has tracked 22,725,280 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,930 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.8. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 198,428 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.