| Title |
Predicted cancer risks induced by computed tomography examinations during childhood, by a quantitative risk assessment approach
|
|---|---|
| Published in |
Radiation and Environmental Biophysics, October 2013
|
| DOI | 10.1007/s00411-013-0491-8 |
| Pubmed ID | |
| Authors |
Neige Journy, Sophie Ancelet, Jean-Luc Rehel, Myriam Mezzarobba, Bernard Aubert, Dominique Laurier, Marie-Odile Bernier |
| Abstract |
The potential adverse effects associated with exposure to ionizing radiation from computed tomography (CT) in pediatrics must be characterized in relation to their expected clinical benefits. Additional epidemiological data are, however, still awaited for providing a lifelong overview of potential cancer risks. This paper gives predictions of potential lifetime risks of cancer incidence that would be induced by CT examinations during childhood in French routine practices in pediatrics. Organ doses were estimated from standard radiological protocols in 15 hospitals. Excess risks of leukemia, brain/central nervous system, breast and thyroid cancers were predicted from dose-response models estimated in the Japanese atomic bomb survivors' dataset and studies of medical exposures. Uncertainty in predictions was quantified using Monte Carlo simulations. This approach predicts that 100,000 skull/brain scans in 5-year-old children would result in eight (90 % uncertainty interval (UI) 1-55) brain/CNS cancers and four (90 % UI 1-14) cases of leukemia and that 100,000 chest scans would lead to 31 (90 % UI 9-101) thyroid cancers, 55 (90 % UI 20-158) breast cancers, and one (90 % UI <0.1-4) leukemia case (all in excess of risks without exposure). Compared to background risks, radiation-induced risks would be low for individuals throughout life, but relative risks would be highest in the first decades of life. Heterogeneity in the radiological protocols across the hospitals implies that 5-10 % of CT examinations would be related to risks 1.4-3.6 times higher than those for the median doses. Overall excess relative risks in exposed populations would be 1-10 % depending on the site of cancer and the duration of follow-up. The results emphasize the potential risks of cancer specifically from standard CT examinations in pediatrics and underline the necessity of optimization of radiological protocols. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 33% |
| China | 1 | 17% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Malaysia | 1 | 1% |
| Brazil | 1 | 1% |
| Belgium | 1 | 1% |
| Spain | 1 | 1% |
| Luxembourg | 1 | 1% |
| Unknown | 63 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 19% |
| Student > Master | 8 | 12% |
| Other | 6 | 9% |
| Student > Bachelor | 6 | 9% |
| Professor | 5 | 7% |
| Other | 12 | 17% |
| Unknown | 19 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 32% |
| Physics and Astronomy | 6 | 9% |
| Nursing and Health Professions | 4 | 6% |
| Agricultural and Biological Sciences | 3 | 4% |
| Biochemistry, Genetics and Molecular Biology | 3 | 4% |
| Other | 8 | 12% |
| Unknown | 23 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2013.
All research outputs
#7,531,172
of 23,815,455 outputs
Outputs from Radiation and Environmental Biophysics
#121
of 456 outputs
Outputs of similar age
#67,871
of 211,569 outputs
Outputs of similar age from Radiation and Environmental Biophysics
#1
of 2 outputs
Altmetric has tracked 23,815,455 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 456 research outputs from this source. They receive a mean Attention Score of 3.9. This one has gotten more attention than average, scoring higher than 73% of its peers.
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We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them