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Genome-wide methylated CpG island profiles of melanoma cells reveal a melanoma coregulation network

Overview of attention for article published in Scientific Reports, October 2013
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Title
Genome-wide methylated CpG island profiles of melanoma cells reveal a melanoma coregulation network
Published in
Scientific Reports, October 2013
DOI 10.1038/srep02962
Pubmed ID
Authors

Jian-Liang Li, Joseph Mazar, Cuncong Zhong, Geoffrey J. Faulkner, Subramaniam S. Govindarajan, Zhan Zhang, Marcel E. Dinger, Gavin Meredith, Christopher Adams, Shaojie Zhang, John S. Mattick, Animesh Ray, Ranjan J. Perera

Abstract

Metastatic melanoma is a malignant cancer with generally poor prognosis, with no targeted chemotherapy. To identify epigenetic changes related to melanoma, we have determined genome-wide methylated CpG island distributions by next-generation sequencing. Melanoma chromosomes tend to be differentially methylated over short CpG island tracts. CpG islands in the upstream regulatory regions of many coding and noncoding RNA genes, including, for example, TERC, which encodes the telomerase RNA, exhibit extensive hypermethylation, whereas several repeated elements, such as LINE 2, and several LTR elements, are hypomethylated in advanced stage melanoma cell lines. By using CpG island demethylation profiles, and by integrating these data with RNA-seq data obtained from melanoma cells, we have identified a co-expression network of differentially methylated genes with significance for cancer related functions. Focused assays of melanoma patient tissue samples for CpG island methylation near the noncoding RNA gene SNORD-10 demonstrated high specificity.

X Demographics

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The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Germany 1 <1%
Uruguay 1 <1%
Korea, Republic of 1 <1%
New Zealand 1 <1%
United Kingdom 1 <1%
Unknown 95 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 24%
Researcher 23 23%
Student > Master 16 16%
Student > Bachelor 7 7%
Student > Doctoral Student 7 7%
Other 19 19%
Unknown 6 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 45 44%
Biochemistry, Genetics and Molecular Biology 24 24%
Medicine and Dentistry 6 6%
Engineering 6 6%
Computer Science 4 4%
Other 7 7%
Unknown 10 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2014.
All research outputs
#12,691,378
of 22,727,570 outputs
Outputs from Scientific Reports
#53,952
of 122,521 outputs
Outputs of similar age
#104,484
of 210,723 outputs
Outputs of similar age from Scientific Reports
#284
of 684 outputs
Altmetric has tracked 22,727,570 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 122,521 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,723 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 684 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.