You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
Attention Score in Context
| Title |
Prefrontal-Related Functional Connectivities within the Default Network Are Modulated by COMT val158met in Healthy Young Adults
|
|---|---|
| Published in |
Journal of Neuroscience, January 2010
|
| DOI | 10.1523/jneurosci.3941-09.2010 |
| Pubmed ID | |
| Authors |
Bing Liu, Ming Song, Jun Li, Yong Liu, Kuncheng Li, Chunshui Yu, Tianzi Jiang |
| Abstract |
Previous studies have supported the concept that the default network is an intrinsic brain system that participates in internal modes of cognition. Neural activity and connectivity within the default network, which are correlated with cognitive ability even at rest, may be plausible intermediate phenotypes that will enable us to understand the genetic mechanisms of individuals' cognitive function or the risk for genetic brain diseases. Using resting functional magnetic resonance imaging and imaging genetic paradigms, we investigated whether individual default network connectivity was modulated by COMT val(158)met in 57 healthy young subjects. Compared with COMT heterozygous individuals, homozygous val individuals showed significantly decreased prefrontal-related connectivities, which primarily occurred between prefrontal regions and the posterior cingulate/restrosplenial cortices. Further analyses of the topological characteristics of the default network showed homozygous val individuals had significantly fewer node degrees in the prefrontal regions. This finding may partially elucidate previous reports that the COMT val variant is associated with inefficient prefrontal information processing and poor cognitive performance. Our findings suggest that default network connectivity that involves the prefrontal cortex is modulated by COMT val(158)met through differential effects on prefrontal dopamine levels. |
Mendeley readers
The data shown below were compiled from readership statistics for 128 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 3% |
| Germany | 2 | 2% |
| China | 2 | 2% |
| Italy | 1 | <1% |
| Sweden | 1 | <1% |
| Canada | 1 | <1% |
| Netherlands | 1 | <1% |
| Russia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 114 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 27% |
| Researcher | 26 | 20% |
| Professor > Associate Professor | 10 | 8% |
| Student > Master | 9 | 7% |
| Professor | 8 | 6% |
| Other | 28 | 22% |
| Unknown | 13 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 44 | 34% |
| Medicine and Dentistry | 19 | 15% |
| Agricultural and Biological Sciences | 18 | 14% |
| Neuroscience | 15 | 12% |
| Biochemistry, Genetics and Molecular Biology | 3 | 2% |
| Other | 10 | 8% |
| Unknown | 19 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2010.
All research outputs
#5,549,652
of 22,727,570 outputs
Outputs from Journal of Neuroscience
#8,954
of 23,154 outputs
Outputs of similar age
#36,186
of 164,021 outputs
Outputs of similar age from Journal of Neuroscience
#63
of 208 outputs
Altmetric has tracked 22,727,570 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 23,154 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.3. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,021 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 208 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.