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Thyroid Cancer Following Childhood Low-Dose Radiation Exposure: A Pooled Analysis of Nine Cohorts

Overview of attention for article published in JCEM, March 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

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1 blog
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421 X users
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1 Google+ user

Citations

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119 Dimensions

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90 Mendeley
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Title
Thyroid Cancer Following Childhood Low-Dose Radiation Exposure: A Pooled Analysis of Nine Cohorts
Published in
JCEM, March 2017
DOI 10.1210/jc.2016-3529
Pubmed ID
Authors

Jay H. Lubin, M. Jacob Adams, Roy Shore, Erik Holmberg, Arthur B. Schneider, Michael M. Hawkins, Leslie L. Robison, Peter D. Inskip, Marie Lundell, Robert Johansson, Ruth A. Kleinerman, Florent de Vathaire, Lena Damber, Siegal Sadetzki, Margaret Tucker, Ritsu Sakata, Lene H. S. Veiga

Abstract

The increased use of diagnostic and therapeutic procedures that involve radiation raises concerns about radiation effects, particularly in children and to the radio-sensitive thyroid gland. Evaluation of relative risk (RR) trends for thyroid radiation doses <0.2 gray; evidence of a threshold dose; and possible modifiers of the dose-response, e.g., sex, age at exposure, time since exposure. Pooled data from nine cohort studies of childhood external radiation exposure and thyroid cancer with individualized dose estimates, ≥1,000 irradiated subjects or ≥10 thyroid cancer cases, with data limited to individuals receiving doses <0.2 gray. Cohorts included: childhood cancer survivors (n=2); children treated for benign diseases (n=6); and children who survived the atomic bombings in Japan (n=1). There were 252 cases and 2,588,559 person-years in irradiated individuals and 142 cases and 1,865,957 person-years in non-irradiated individuals. There were no interventions. Incident thyroid cancers. For both <0.2 gray and <0.1 gray, RRs increased with thyroid dose (P<0.01), without significant departure from linearity (P=0.77 and P=0.66, respectively). Estimates of threshold dose ranged from 0.0 to 0.03 gray, with an upper 95% confidence bound of 0.04 gray. The increasing dose-response trend persisted >45 years after exposure, was greater at younger age at exposure and younger attained age and was similar by sex and number of treatments. Our analyses reaffirmed linearity of the dose-response as the most plausible relationship for ALARA ("as low as reasonably achievable") assessments for pediatric low dose radiation-associated thyroid cancer risk.

X Demographics

X Demographics

The data shown below were collected from the profiles of 421 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 90 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 13%
Student > Ph. D. Student 9 10%
Student > Master 9 10%
Student > Bachelor 8 9%
Professor 5 6%
Other 19 21%
Unknown 28 31%
Readers by discipline Count As %
Medicine and Dentistry 28 31%
Nursing and Health Professions 9 10%
Biochemistry, Genetics and Molecular Biology 5 6%
Engineering 3 3%
Physics and Astronomy 3 3%
Other 10 11%
Unknown 32 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 307. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 September 2023.
All research outputs
#113,449
of 25,728,855 outputs
Outputs from JCEM
#106
of 15,525 outputs
Outputs of similar age
#2,650
of 322,061 outputs
Outputs of similar age from JCEM
#2
of 103 outputs
Altmetric has tracked 25,728,855 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,525 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,061 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 103 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.