Title |
Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure
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Published in |
Nature Genetics, February 2009
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DOI | 10.1038/ng.328 |
Pubmed ID | |
Authors |
Christopher Newton-Cheh, Martin G Larson, Ramachandran S Vasan, Daniel Levy, Kenneth D Bloch, Aarti Surti, Candace Guiducci, Sekar Kathiresan, Emelia J Benjamin, Joachim Struck, Nils G Morgenthaler, Andreas Bergmann, Stefan Blankenberg, Frank Kee, Peter Nilsson, Xiaoyan Yin, Leena Peltonen, Erkki Vartiainen, Veikko Salomaa, Joel N Hirschhorn, Olle Melander, Thomas J Wang |
Abstract |
We examined the association of common variants at the NPPA-NPPB locus with circulating concentrations of the natriuretic peptides, which have blood pressure-lowering properties. We genotyped SNPs at the NPPA-NPPB locus in 14,743 individuals of European ancestry, and identified associations of plasma atrial natriuretic peptide with rs5068 (P = 8 x 10(-70)), rs198358 (P = 8 x 10(-30)) and rs632793 (P = 2 x 10(-10)), and of plasma B-type natriuretic peptide with rs5068 (P = 3 x 10(-12)), rs198358 (P = 1 x 10(-25)) and rs632793 (P = 2 x 10(-68)). In 29,717 individuals, the alleles of rs5068 and rs198358 that showed association with increased circulating natriuretic peptide concentrations were also found to be associated with lower systolic (P = 2 x 10(-6) and 6 x 10(-5), respectively) and diastolic blood pressure (P = 1 x 10(-6) and 5 x 10(-5)), as well as reduced odds of hypertension (OR = 0.85, 95% CI = 0.79-0.92, P = 4 x 10(-5); OR = 0.90, 95% CI = 0.85-0.95, P = 2 x 10(-4), respectively). Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Italy | 1 | <1% |
Uruguay | 1 | <1% |
Brazil | 1 | <1% |
Sweden | 1 | <1% |
United Kingdom | 1 | <1% |
New Zealand | 1 | <1% |
Belgium | 1 | <1% |
United States | 1 | <1% |
Unknown | 136 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 37 | 26% |
Student > Ph. D. Student | 17 | 12% |
Professor | 14 | 10% |
Student > Bachelor | 12 | 8% |
Professor > Associate Professor | 10 | 7% |
Other | 32 | 22% |
Unknown | 22 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 45 | 31% |
Agricultural and Biological Sciences | 28 | 19% |
Biochemistry, Genetics and Molecular Biology | 13 | 9% |
Mathematics | 4 | 3% |
Chemistry | 3 | 2% |
Other | 18 | 13% |
Unknown | 33 | 23% |