| Title |
Structural basis of Zika virus methyltransferase inhibition by sinefungin
|
|---|---|
| Published in |
Archives of Virology, March 2017
|
| DOI | 10.1007/s00705-017-3345-x |
| Pubmed ID | |
| Authors |
Kamil Hercik, Jiri Brynda, Radim Nencka, Evzen Boura |
| Abstract |
Zika virus is considered a major global threat to human kind. Here, we present a crystal structure of one of its essential enzymes, the methyltransferase, with the inhibitor sinefungin. This structure, together with previously solved structures with bound substrates, will provide the information needed for rational inhibitor design. Based on the structural data we suggest the modification of the adenine moiety of sinefungin to increase selectivity and to covalently link it to a GTP analogue, to increase the affinity of the synthesized compounds. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Czechia | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 74 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 12% |
| Student > Master | 9 | 12% |
| Student > Bachelor | 9 | 12% |
| Researcher | 7 | 9% |
| Professor > Associate Professor | 4 | 5% |
| Other | 11 | 15% |
| Unknown | 25 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 17 | 23% |
| Biochemistry, Genetics and Molecular Biology | 6 | 8% |
| Agricultural and Biological Sciences | 6 | 8% |
| Immunology and Microbiology | 5 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
| Other | 9 | 12% |
| Unknown | 28 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 April 2017.
All research outputs
#15,175,585
of 24,093,053 outputs
Outputs from Archives of Virology
#2,516
of 4,318 outputs
Outputs of similar age
#177,091
of 312,182 outputs
Outputs of similar age from Archives of Virology
#18
of 82 outputs
Altmetric has tracked 24,093,053 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,318 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
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We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.