| Title |
In vivo imaging of oxidative stress and fronto-limbic white matter integrity in young adults with mood disorders
|
|---|---|
| Published in |
European Archives of Psychiatry and Clinical Neuroscience, March 2017
|
| DOI | 10.1007/s00406-017-0788-8 |
| Pubmed ID | |
| Authors |
Daniel F. Hermens, Sean N. Hatton, Rico S. C. Lee, Sharon L. Naismith, Shantel L. Duffy, G. Paul Amminger, Manreena Kaur, Elizabeth M. Scott, Jim Lagopoulos, Ian B. Hickie |
| Abstract |
Fronto-limbic connectivity is compromised in mood disorders, as reflected by impairments in white matter (WM) integrity revealed by diffusion tensor imaging. Although the underlying mechanisms remain unclear, disruption to normal myelination due to oxidative stress is thought to play a key role. We aimed to determine whether fronto-limbic WM integrity is compromised, and associated with in vivo antioxidant levels (indexed by glutathione; GSH), in young adults with unipolar depression (DEP) and bipolar (BD) disorders. Ninety-four patients with DEP, 76 with BD and 59 healthy controls (18-30 years) underwent diffusion tensor and proton magnetic resonance spectroscopy imaging. Fractional anisotropy (FA) was calculated from the cingulum bundle (cingulate, hippocampus), fornix, stria terminalis (ST) and uncinate fasciculus tracts. GSH concentration was measured in anterior cingulate cortex (ACC) and hippocampus (HIPP). Compared to controls, DEP showed significantly reduced FA in ST, whereas BD did not significantly differ in FA across the five tracts. There were significant positive correlations between ST-FA and HIPP-GSH across groups. Regression analysis revealed that having DEP or BD and reduced HIPP-GSH were significantly associated with reduced ST-FA. Similarly, decreased ST-FA was associated with poorer neuropsychological performance in conjunction with having DEP. Our findings suggest a structural disconnectivity specific to the limbic region of young adults with DEP. Decreased WM integrity was associated with depleted levels of hippocampal GSH suggesting that this particular disruption may be linked to oxidative stress at early stages of illness. Young adults with BD do not have the same degree of impairment. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 50% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 60 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 13% |
| Student > Bachelor | 7 | 12% |
| Student > Master | 5 | 8% |
| Student > Doctoral Student | 4 | 7% |
| Researcher | 4 | 7% |
| Other | 9 | 15% |
| Unknown | 23 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 11 | 18% |
| Neuroscience | 9 | 15% |
| Medicine and Dentistry | 6 | 10% |
| Biochemistry, Genetics and Molecular Biology | 3 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Other | 7 | 12% |
| Unknown | 22 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2017.
All research outputs
#14,065,859
of 23,815,455 outputs
Outputs from European Archives of Psychiatry and Clinical Neuroscience
#706
of 1,243 outputs
Outputs of similar age
#161,221
of 310,282 outputs
Outputs of similar age from European Archives of Psychiatry and Clinical Neuroscience
#10
of 30 outputs
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So far Altmetric has tracked 1,243 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
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We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.