Title |
Adolescent social defeat decreases spatial working memory performance in adulthood
|
---|---|
Published in |
Behavioral and Brain Functions, October 2013
|
DOI | 10.1186/1744-9081-9-39 |
Pubmed ID | |
Authors |
Andrew M Novick, Leah C Miiller, Gina L Forster, Michael J Watt |
Abstract |
Adolescent social stress is associated with increased incidence of mental illnesses in adulthood that are characterized by deficits in cognitive focus and flexibility. Such enhanced vulnerability may be due to psychosocial stress-induced disruption of the developing mesocortical dopamine system, which plays a fundamental role in facilitating complex cognitive processes such as spatial working memory. Adolescent rats exposed to repeated social defeat as a model of social stress develop dopaminergic hypofunction in the medial prefrontal cortex as adults. To evaluate a direct link between adolescent social stress and later deficits in cognitive function, the present study tested the effects of adolescent social defeat on two separate tests of spatial working memory performance. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 40% |
United Kingdom | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | <1% |
Unknown | 112 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 26 | 23% |
Student > Master | 15 | 13% |
Student > Bachelor | 12 | 11% |
Researcher | 11 | 10% |
Other | 7 | 6% |
Other | 20 | 18% |
Unknown | 22 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 25 | 22% |
Neuroscience | 24 | 21% |
Psychology | 13 | 12% |
Medicine and Dentistry | 8 | 7% |
Nursing and Health Professions | 3 | 3% |
Other | 12 | 11% |
Unknown | 28 | 25% |