| Title |
Vascular damage in obese female rats with hypoestrogenism
|
|---|---|
| Published in |
Journal of Physiology and Biochemistry, August 2013
|
| DOI | 10.1007/s13105-013-0283-2 |
| Pubmed ID | |
| Authors |
Luis Angel Lima-Mendoza, Juventino Colado-Velázquez, Patrick Mailloux-Salinas, Josué V. Espinosa-Juárez, Norma L. Gómez-Viquez, Tzindilu Molina-Muñoz, Fengyang Huang, Guadalupe Bravo |
| Abstract |
Increase in body weight and adiposity has deleterious consequences on health. The aim of this study was to compare morphological and metabolic changes in the arterial vessels of Wistar rats with conditions of obesity, hypoestrogenism, and hypoestrogenism plus obesity. Ovariectomized rats (hypoestrogenic condition) received 30 % sugar in drinking water plus standard diet during 10 weeks. The hypoestrogenic-obese (HE-OB) group presented increase in weight, blood pressure, hypertriglyceridemia, and hyperglycemia compared with other groups. The morphological study in aortic vessels from HE showed damage in endothelial smooth muscle tissue compared with the other groups. Adipose cells volume in HE-OB (59.33 ± 2.38 μ(3) × 10(5)) and obese (OB) (54.95 ± 1.36 μ(3) × 10(5)) groups were significantly larger than control group (36.38 ± 0.98 μ(3) × 10(5)). In the HE group adipocyte hyperplasia was observed, while in OB group adipocyte hypertrophy and hyperplasia was shown. The vascular reactivity in HE-OB and OB groups presented decrease in the relaxation to acetylcholine compared with control conditions (p < 0.05), whereas the addition of N(G)-nitro-L-arginine methyl ester resulted in a greater inhibition of relaxation in HE-OB and OB groups compared with control conditions (p < 0.05). These findings suggest that the dysfunction in blood vessels observed in estrogen deficiency and obesity conditions contributes to early cardiovascular alterations. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 23 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 5 | 22% |
| Student > Bachelor | 4 | 17% |
| Student > Master | 3 | 13% |
| Professor | 2 | 9% |
| Student > Ph. D. Student | 2 | 9% |
| Other | 4 | 17% |
| Unknown | 3 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 30% |
| Medicine and Dentistry | 6 | 26% |
| Nursing and Health Professions | 2 | 9% |
| Neuroscience | 2 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 4 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2013.
All research outputs
#18,351,676
of 22,727,570 outputs
Outputs from Journal of Physiology and Biochemistry
#404
of 527 outputs
Outputs of similar age
#149,667
of 200,088 outputs
Outputs of similar age from Journal of Physiology and Biochemistry
#4
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