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Research Resource: Nuclear Receptors as Transcriptome: Discriminant and Prognostic Value in Breast Cancer

Overview of attention for article published in Molecular Endocrinology, January 2013
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Title
Research Resource: Nuclear Receptors as Transcriptome: Discriminant and Prognostic Value in Breast Cancer
Published in
Molecular Endocrinology, January 2013
DOI 10.1210/me.2012-1265
Pubmed ID
Authors

George E. O. Muscat, Natalie A. Eriksson, Karen Byth, Sherene Loi, Dinny Graham, Shalini Jindal, Melissa J. Davis, Colin Clyne, John W. Funder, Evan R. Simpson, Mark A. Ragan, Elizabeth Kuczek, Peter J. Fuller, Wayne D. Tilley, Peter J. Leedman, Christine L. Clarke

Abstract

To identify biologically relevant groupings or clusters of nuclear receptors (NR) that are associated with breast neoplasia, with potentially diagnostic, discriminant or prognostic value, we quantitated mRNA expression levels of all 48 members of the human NR superfamily by TaqMan low-density array analysis in 116 curated breast tissue samples, including pre- and postmenopausal normal breast and both ERα(+) and ERα(-) tumor tissue. In addition, we have determined NR levels in independent cohorts of tamoxifen-treated ERα(+) and ERα(-) tissue samples. There were differences in relative NR mRNA expression between neoplastic and normal breast, and between ER(+) and ER(-) tumors. First, there is overexpression of the NUR77 subgroup and EAR2 in neoplastic breast. Second, we identify a signature of five NR (ERα, EAR2, NUR77, TRα, and RARγ) that classifies breast samples with more than 97% cross-validated accuracy into normal or cancer classes. Third, we find a novel negative association between five NR (TRβ, NUR77, RORγ, COUP-TFII, and LRH1) and histological grade. Finally, four NR (COUP-TFII, TRβ, PPARγ, and MR) are significant predictors of metastasis-free survival in tamoxifen-treated breast cancers, independent of ER expression. The present study highlights the discriminant and prognostic value of NR in breast cancer; identifies novel, clinically relevant, NR signatures; and highlights NR signaling pathways with potential roles in breast cancer pathophysiology and as new therapeutic targets.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 3%
Hungary 1 2%
Australia 1 2%
Unknown 62 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 24%
Student > Ph. D. Student 12 18%
Student > Master 11 17%
Student > Bachelor 9 14%
Other 4 6%
Other 6 9%
Unknown 8 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 27%
Biochemistry, Genetics and Molecular Biology 15 23%
Medicine and Dentistry 14 21%
Chemistry 5 8%
Computer Science 3 5%
Other 4 6%
Unknown 7 11%