| Title |
A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs
|
|---|---|
| Published in |
GeroScience, April 2017
|
| DOI | 10.1007/s11357-017-9972-z |
| Pubmed ID | |
| Authors |
Silvan R. Urfer, Tammi L. Kaeberlein, Susan Mailheau, Philip J. Bergman, Kate E. Creevy, Daniel E. L. Promislow, Matt Kaeberlein |
| Abstract |
Age is the single greatest risk factor for most causes of morbidity and mortality in humans and their companion animals. As opposed to other model organisms used to study aging, dogs share the human environment, are subject to similar risk factors, receive comparable medical care, and develop many of the same age-related diseases humans do. In this study, 24 middle-aged healthy dogs received either placebo or a non-immunosuppressive dose of rapamycin for 10 weeks. All dogs received clinical and hematological exams before, during, and after the trial and echocardiography before and after the trial. Our results showed no clinical side effects in the rapamycin-treated group compared to dogs receiving the placebo. Echocardiography suggested improvement in both diastolic and systolic age-related measures of heart function (E/A ratio, fractional shortening, and ejection fraction) in the rapamycin-treated dogs. Hematological values remained within the normal range for all parameters studied; however, the mean corpuscular volume (MCV) was decreased in rapamycin-treated dogs. Based on these results, we will test rapamycin on a larger dog cohort for a longer period of time in order to validate its effects on cardiac function and to determine whether it can significantly improve healthspan and reduce mortality in companion dogs. |
X Demographics
The data shown below were collected from the profiles of 58 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 21 | 36% |
| United Kingdom | 7 | 12% |
| India | 1 | 2% |
| Canada | 1 | 2% |
| Netherlands | 1 | 2% |
| Turkey | 1 | 2% |
| Germany | 1 | 2% |
| Mexico | 1 | 2% |
| Unknown | 24 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 35 | 60% |
| Scientists | 17 | 29% |
| Practitioners (doctors, other healthcare professionals) | 4 | 7% |
| Science communicators (journalists, bloggers, editors) | 2 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 130 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 1 | <1% |
| Unknown | 129 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 17% |
| Student > Bachelor | 17 | 13% |
| Researcher | 16 | 12% |
| Other | 14 | 11% |
| Student > Master | 12 | 9% |
| Other | 18 | 14% |
| Unknown | 31 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 29 | 22% |
| Agricultural and Biological Sciences | 16 | 12% |
| Veterinary Science and Veterinary Medicine | 12 | 9% |
| Medicine and Dentistry | 11 | 8% |
| Computer Science | 4 | 3% |
| Other | 22 | 17% |
| Unknown | 36 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 354. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2024.
All research outputs
#92,385
of 26,017,215 outputs
Outputs from GeroScience
#12
of 1,651 outputs
Outputs of similar age
#2,189
of 327,723 outputs
Outputs of similar age from GeroScience
#1
of 12 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,651 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,723 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.