| Title |
The Burden and Long-term Respiratory Morbidity Associated with Respiratory Syncytial Virus Infection in Early Childhood
|
|---|---|
| Published in |
Infectious Diseases and Therapy, March 2017
|
| DOI | 10.1007/s40121-017-0151-4 |
| Pubmed ID | |
| Authors |
Brigitte Fauroux, Eric A. F. Simões, Paul A. Checchia, Bosco Paes, Josep Figueras-Aloy, Paolo Manzoni, Louis Bont, Xavier Carbonell-Estrany |
| Abstract |
The REGAL (RSV Evidence-a Geographical Archive of the Literature) series provide a comprehensive review of the published evidence in the field of respiratory syncytial virus (RSV) in Western countries over the last 20 years. The objective of this fifth publication was to determine the long-term respiratory morbidity associated with RSV lower respiratory tract infection (RSV LRTI) in early life. A systematic review was undertaken for articles published between January 1, 1995 and December 31, 2015. This was supplemented by inclusion of papers published whilst drafting the manuscript. Studies reporting data on the incidence and long-term wheezing and asthma following RSV LRTI in early life were included. Study quality and strength of evidence (SOE) were graded using recognized criteria. A total of 2337 studies were identified of which 74 were included. Prospective, epidemiologic studies consistently demonstrated that RSV LRTI is a significant risk factor for on-going respiratory morbidity characterized by transient early wheezing and recurrent wheezing and asthma within the first decade of life and possibly into adolescence and adulthood (high SOE). RSV LRTI was also associated with impaired lung function in these children (high SOE). Respiratory morbidity has been shown to result in reduced quality of life and increased healthcare resource use (moderate SOE). The mechanisms through which RSV contributes to wheezing/asthma development are not fully understood, but appear to relate to the viral injury, preexisting abnormal lung function and/or other factors that predispose to wheezing/asthma, including genetic susceptibility, altered immunology, eosinophilia, and associated risk factors such as exposure to environmental tobacco smoke (high SOE). There is growing evidence that RSV LRTI in early childhood is associated with long-term wheezing and asthma and impaired lung function. Future research should aim to fully elucidate the pathophysiological mechanisms through which RSV causes recurrent wheezing/asthma. |
X Demographics
The data shown below were collected from the profiles of 587 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 71 | 12% |
| Canada | 54 | 9% |
| United Kingdom | 30 | 5% |
| Germany | 16 | 3% |
| Japan | 15 | 3% |
| Australia | 13 | 2% |
| Spain | 13 | 2% |
| Sweden | 8 | 1% |
| Netherlands | 6 | 1% |
| Other | 41 | 7% |
| Unknown | 320 | 55% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 532 | 91% |
| Practitioners (doctors, other healthcare professionals) | 23 | 4% |
| Scientists | 20 | 3% |
| Science communicators (journalists, bloggers, editors) | 12 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 182 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Unknown | 181 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 15% |
| Researcher | 19 | 10% |
| Student > Master | 16 | 9% |
| Student > Bachelor | 14 | 8% |
| Other | 13 | 7% |
| Other | 32 | 18% |
| Unknown | 61 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 58 | 32% |
| Biochemistry, Genetics and Molecular Biology | 12 | 7% |
| Immunology and Microbiology | 12 | 7% |
| Agricultural and Biological Sciences | 7 | 4% |
| Nursing and Health Professions | 7 | 4% |
| Other | 17 | 9% |
| Unknown | 69 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 322. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 September 2023.
All research outputs
#106,428
of 25,766,791 outputs
Outputs from Infectious Diseases and Therapy
#8
of 870 outputs
Outputs of similar age
#2,471
of 324,242 outputs
Outputs of similar age from Infectious Diseases and Therapy
#1
of 11 outputs
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So far Altmetric has tracked 870 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.1. This one has done particularly well, scoring higher than 99% of its peers.
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