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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genetic signatures of high-altitude adaptation in Tibetans
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, April 2017
|
| DOI | 10.1073/pnas.1617042114 |
| Pubmed ID | |
| Authors |
Jian Yang, Zi-Bing Jin, Jie Chen, Xiu-Feng Huang, Xiao-Man Li, Yuan-Bo Liang, Jian-Yang Mao, Xin Chen, Zhili Zheng, Andrew Bakshi, Dong-Dong Zheng, Mei-Qin Zheng, Naomi R Wray, Peter M Visscher, Fan Lu, Jia Qu |
| Abstract |
Indigenous Tibetan people have lived on the Tibetan Plateau for millennia. There is a long-standing question about the genetic basis of high-altitude adaptation in Tibetans. We conduct a genome-wide study of 7.3 million genotyped and imputed SNPs of 3,008 Tibetans and 7,287 non-Tibetan individuals of Eastern Asian ancestry. Using this large dataset, we detect signals of high-altitude adaptation at nine genomic loci, of which seven are unique. The alleles under natural selection at two of these loci [methylenetetrahydrofolate reductase (MTHFR) and EPAS1] are strongly associated with blood-related phenotypes, such as hemoglobin, homocysteine, and folate in Tibetans. The folate-increasing allele of rs1801133 at the MTHFR locus has an increased frequency in Tibetans more than expected under a drift model, which is probably a consequence of adaptation to high UV radiation. These findings provide important insights into understanding the genomic consequences of high-altitude adaptation in Tibetans. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 10% |
| Netherlands | 1 | 5% |
| United Kingdom | 1 | 5% |
| Indonesia | 1 | 5% |
| Slovenia | 1 | 5% |
| Spain | 1 | 5% |
| Australia | 1 | 5% |
| Denmark | 1 | 5% |
| Unknown | 12 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 52% |
| Scientists | 6 | 29% |
| Practitioners (doctors, other healthcare professionals) | 3 | 14% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 231 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Mexico | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 228 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 54 | 23% |
| Researcher | 42 | 18% |
| Student > Bachelor | 27 | 12% |
| Student > Master | 24 | 10% |
| Professor > Associate Professor | 10 | 4% |
| Other | 29 | 13% |
| Unknown | 45 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 64 | 28% |
| Biochemistry, Genetics and Molecular Biology | 54 | 23% |
| Medicine and Dentistry | 21 | 9% |
| Social Sciences | 5 | 2% |
| Immunology and Microbiology | 4 | 2% |
| Other | 26 | 11% |
| Unknown | 57 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 104. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2021.
All research outputs
#386,530
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#7,037
of 101,438 outputs
Outputs of similar age
#8,329
of 313,561 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#136
of 897 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,561 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 897 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.