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Mendeley readers
Attention Score in Context
| Title |
Cerebrospinal Fluid Cytokines Correlate With Aseptic Meningitis and Blood–Brain Barrier Function in Neonatal‐Onset Multisystem Inflammatory Disease: Central Nervous System Biomarkers in Neonatal‐Onset Multisystem Inflammatory Disease Correlate With Central Nervous System Inflammation
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|---|---|
| Published in |
Arthritis & Rheumatology, May 2017
|
| DOI | 10.1002/art.40055 |
| Pubmed ID | |
| Authors |
Jackeline Rodriguez‐Smith, Yen‐Chih Lin, Wanxia Li Tsai, Hanna Kim, Gina Montealegre‐Sanchez, Dawn Chapelle, Yan Huang, Cailin H. Sibley, Massimo Gadina, Robert Wesley, Bibiana Bielekova, Raphaela Goldbach‐Mansky |
| Abstract |
To evaluate proinflammatory cytokines and leukocyte subpopulations in cerebrospinal spinal fluid (CSF) and blood of NOMID patients post-treatment; and to compare inflammatory cytokines in CSF and blood in 6 patients treated with two IL-1 blockers, anakinra and canakinumab. We immunophenotyped CSF on 17 anakinra-treated pediatric NOMID patients during routine follow-up visits between December 2011 and October 2013 and analyzed CSF cytokine levels in baseline and 3-5 years follow-up samples compared to healthy controls. Elevated CSF IL-6, IP-10/CXCL10, IL-18 levels, and monocyte and granulocytes counts significantly decreased with anakinra treatment, but did not normalize to control levels, even in patients fulfilling criteria of "clinical remission" (CR). CSF IL-6 and IL-18 levels significantly correlate with measures of blood brain barrier (BBB) function, specifically CSF protein (r=0.75; r=0.81 respectively); and albumin quotient (r=0.79, r=0.68 respectively). Median CSF WBC levels (10.2 vs. 3.7cell/mm3) and CSF IL-6 levels (150.7 vs. 28.5pg/ml) were significantly higher when patients received canakinumab than anakinra despite similar serum cytokine levels. CSF leukocyte subpopulations and cytokine levels significantly improve with optimized IL-1 blocking treatment but do not normalize. The correlation of CSF IL-6, IP-10/CXCL10 and IL-18 with clinical-laboratory measures of inflammation and BBB function suggests a role as biomarkers in CNS inflammation. The difference in inhibition of CSF biomarkers between two IL-1 blocking agents, anakinra and canakinumab, suggests differences in efficacy in the intrathecal compartment, with anakinra being more effective. Our data indicate that intrathecal immune responses shape CNS inflammation and should be assessed in addition to blood markers. This article is protected by copyright. All rights reserved. |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 41 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 17% |
| Student > Doctoral Student | 7 | 17% |
| Other | 6 | 15% |
| Student > Postgraduate | 5 | 12% |
| Professor > Associate Professor | 3 | 7% |
| Other | 8 | 20% |
| Unknown | 5 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 54% |
| Neuroscience | 3 | 7% |
| Nursing and Health Professions | 2 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
| Agricultural and Biological Sciences | 2 | 5% |
| Other | 3 | 7% |
| Unknown | 7 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2017.
All research outputs
#20,412,387
of 22,962,258 outputs
Outputs from Arthritis & Rheumatology
#2,549
of 2,771 outputs
Outputs of similar age
#270,503
of 310,731 outputs
Outputs of similar age from Arthritis & Rheumatology
#75
of 78 outputs
Altmetric has tracked 22,962,258 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,771 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,731 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.