| Title |
Frequency of HLA-A*03 associates with HIV-1 infection in a Chinese cohort
|
|---|---|
| Published in |
Science China Life Sciences, October 2013
|
| DOI | 10.1007/s11427-013-4555-4 |
| Pubmed ID | |
| Authors |
WeiLun Zhang, Li Wang, KunXue Hong, YanXin Liu, Bing Su, Cheng Xu, JianQin Xu, YuHua Ruan, YiMin Shao, DeXian Zheng |
| Abstract |
During the early mid-1990s, a number of rural farmers across central China were employed to the unregulated plasmaselling-activity and many of them were infected by HIV-1. However, AIDS progression in the former blood donors (FBDs) is various. The aim of this study is to assess human leukocyte antigen (HLA) class I allele distribution in FBDs and evaluate its association with HIV-1 infection and disease progression. A total of 353 FBDs were enrolled in the cohort including 294 ART naïve HIV-1 seropositive and 59 HIV-1 seronegative age-matched subjects. The viral load and CD4/CD8 T cell counts were assessed in all subjects. Compared with HIV-seropositive group, the frequency of HLA-A 03 in control was significantly higher. After classifying the HLA-B alleles of the subjects according to the presence of Bw4/Bw6 serological epitopes, detrimental effect of HLA Bw6/ Bw6 homozygosity was also confirmed in the HIV-seropositive subjects. This study provides novel evidence on HLA class I allele distribution and association of HLA-A 03 frequency with HIV-1 infection and viremia in the HIV-1 infected FBDs, which may throw light on intervention strategy for the HIV-1 infection and our understanding how host immunity and genetic background affect HIV infection and AIDS progression. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Hungary | 1 | 8% |
| Unknown | 11 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 25% |
| Student > Bachelor | 3 | 25% |
| Other | 1 | 8% |
| Student > Master | 1 | 8% |
| Student > Ph. D. Student | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 3 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 33% |
| Biochemistry, Genetics and Molecular Biology | 2 | 17% |
| Agricultural and Biological Sciences | 2 | 17% |
| Immunology and Microbiology | 1 | 8% |
| Unknown | 3 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 October 2013.
All research outputs
#18,351,676
of 22,727,570 outputs
Outputs from Science China Life Sciences
#615
of 998 outputs
Outputs of similar age
#156,259
of 209,635 outputs
Outputs of similar age from Science China Life Sciences
#3
of 8 outputs
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So far Altmetric has tracked 998 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.4. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
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