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Attention Score in Context
| Title |
MEN ε/β nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles
|
|---|---|
| Published in |
Genome Research, December 2008
|
| DOI | 10.1101/gr.087775.108 |
| Pubmed ID | |
| Authors |
Hongjae Sunwoo, Marcel E. Dinger, Jeremy E. Wilusz, Paulo P. Amaral, John S. Mattick, David L. Spector |
| Abstract |
Studies of the transcriptional output of the human and mouse genomes have revealed that there are many more transcripts produced than can be accounted for by predicted protein-coding genes. Using a custom microarray, we have identified 184 non-coding RNAs that exhibit more than twofold up- or down-regulation upon differentiation of C2C12 myoblasts into myotubes. Here, we focus on the Men epsilon/beta locus, which is up-regulated 3.3-fold during differentiation. Two non-coding RNA isoforms are produced from a single RNA polymerase II promoter, differing in the location of their 3' ends. Men epsilon is a 3.2-kb polyadenylated RNA, whereas Men beta is an approximately 20-kb transcript containing a genomically encoded poly(A)-rich tract at its 3'-end. The 3'-end of Men beta is generated by RNase P cleavage. The Men epsilon/beta transcripts are localized to nuclear paraspeckles and directly interact with NONO. Knockdown of MEN epsilon/beta expression results in the disruption of nuclear paraspeckles. Furthermore, the formation of paraspeckles, after release from transcriptional inhibition by DRB treatment, was suppressed in MEN epsilon/beta-depleted cells. Our findings indicate that the MEN epsilon/beta non-coding RNAs are essential structural/organizational components of paraspeckles. |
Mendeley readers
The data shown below were compiled from readership statistics for 331 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 6 | 2% |
| United States | 4 | 1% |
| Germany | 2 | <1% |
| Japan | 2 | <1% |
| Australia | 1 | <1% |
| Slovenia | 1 | <1% |
| Unknown | 315 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 79 | 24% |
| Researcher | 64 | 19% |
| Student > Master | 42 | 13% |
| Professor | 22 | 7% |
| Student > Bachelor | 21 | 6% |
| Other | 60 | 18% |
| Unknown | 43 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 131 | 40% |
| Biochemistry, Genetics and Molecular Biology | 120 | 36% |
| Medicine and Dentistry | 11 | 3% |
| Neuroscience | 7 | 2% |
| Immunology and Microbiology | 4 | 1% |
| Other | 14 | 4% |
| Unknown | 44 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 38. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2024.
All research outputs
#1,057,644
of 25,373,627 outputs
Outputs from Genome Research
#390
of 4,425 outputs
Outputs of similar age
#3,673
of 182,836 outputs
Outputs of similar age from Genome Research
#2
of 35 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,425 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.3. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 182,836 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.