Title |
Different clinical characteristics associated with acute bleeding and delayed bleeding after endoscopic submucosal dissection in patients with early gastric cancer
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Published in |
Surgical Endoscopy, April 2017
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DOI | 10.1007/s00464-017-5513-1 |
Pubmed ID | |
Authors |
Takafumi Yano, Satoshi Tanabe, Kenji Ishido, Mizuto Suzuki, Natsuko Kawanishi, Sakiko Yamane, Akinori Watanabe, Takuya Wada, Mizutomo Azuma, Chikatoshi Katada, Wasaburo Koizumi |
Abstract |
Few studies have classified risk factors according to the onset time of bleeding after endoscopic submucosal dissection (post-ESD bleeding). We studied 1767 consecutive lesions in patients who underwent ESD for early gastric cancer from December 2006 through June 2016. Patients who had a remnant stomach or who had undergone reconstruction with a gastric tube were excluded. Post-ESD bleeding was classified into acute bleeding (0-5 days after ESD) and delayed bleeding (6 or more days after ESD), and the risk factors for each type of bleeding were compared. Post-ESD bleeding occurred in 150 (8.5%) of 1767 lesions. Bleeding was acute in 129 lesions (7.3%) and delayed in 21 (1.2%). Acute post-ESD bleeding was frequently associated with lesions located in the distal stomach, expanded indications or non-indicated lesions, a specimen diameter of ≥40 mm, and antithrombotic therapy. Delayed post-ESD bleeding was often associated with lesions located in the proximal stomach, hemodialysis, and antithrombotic therapy. Among 334 lesions in patients who received antithrombotic therapy, post-ESD bleeding occurred in 47 lesions (14.1%). Independent risk factors for post-ESD bleeding were a specimen diameter of ≥40 mm and treatment with 2 or more antithrombotic agents. Acute post-ESD bleeding and delayed post-ESD bleeding were associated with different clinical characteristics. Antithrombotic therapy is a risk factor for post-ESD bleeding in both the acute and delayed phases. |
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Mendeley readers
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Demographic breakdown
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Student > Master | 3 | 20% |
Student > Ph. D. Student | 3 | 20% |
Researcher | 2 | 13% |
Librarian | 1 | 7% |
Lecturer > Senior Lecturer | 1 | 7% |
Other | 2 | 13% |
Unknown | 3 | 20% |
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Psychology | 1 | 7% |
Nursing and Health Professions | 1 | 7% |
Chemistry | 1 | 7% |
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Other | 0 | 0% |
Unknown | 4 | 27% |