Title |
Detection of Tuberculosis in HIV-Infected and -Uninfected African Adults Using Whole Blood RNA Expression Signatures: A Case-Control Study
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Published in |
PLOS Medicine, October 2013
|
DOI | 10.1371/journal.pmed.1001538 |
Pubmed ID | |
Authors |
Myrsini Kaforou, Victoria J. Wright, Tolu Oni, Neil French, Suzanne T. Anderson, Nonzwakazi Bangani, Claire M. Banwell, Andrew J. Brent, Amelia C. Crampin, Hazel M. Dockrell, Brian Eley, Robert S. Heyderman, Martin L. Hibberd, Florian Kern, Paul R. Langford, Ling Ling, Marc Mendelson, Tom H. Ottenhoff, Femia Zgambo, Robert J. Wilkinson, Lachlan J. Coin, Michael Levin |
Abstract |
A major impediment to tuberculosis control in Africa is the difficulty in diagnosing active tuberculosis (TB), particularly in the context of HIV infection. We hypothesized that a unique host blood RNA transcriptional signature would distinguish TB from other diseases (OD) in HIV-infected and -uninfected patients, and that this could be the basis of a simple diagnostic test. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 13% |
United Arab Emirates | 1 | 6% |
Saudi Arabia | 1 | 6% |
United Kingdom | 1 | 6% |
Mexico | 1 | 6% |
Unknown | 10 | 63% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 63% |
Scientists | 3 | 19% |
Practitioners (doctors, other healthcare professionals) | 2 | 13% |
Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | <1% |
United States | 2 | <1% |
Brazil | 1 | <1% |
Canada | 1 | <1% |
Kenya | 1 | <1% |
Unknown | 294 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 75 | 25% |
Student > Ph. D. Student | 48 | 16% |
Student > Master | 37 | 12% |
Student > Doctoral Student | 18 | 6% |
Student > Bachelor | 14 | 5% |
Other | 50 | 17% |
Unknown | 59 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 69 | 23% |
Agricultural and Biological Sciences | 59 | 20% |
Biochemistry, Genetics and Molecular Biology | 40 | 13% |
Immunology and Microbiology | 36 | 12% |
Nursing and Health Professions | 7 | 2% |
Other | 23 | 8% |
Unknown | 67 | 22% |