| Title |
The Effects of Sertraline on Fathead Minnow (Pimephales promelas) Growth and Steroidogenesis
|
|---|---|
| Published in |
Bulletin of Environmental Contamination and Toxicology, April 2017
|
| DOI | 10.1007/s00128-017-2079-5 |
| Pubmed ID | |
| Authors |
D. R. Carty, D. Hala, D. B. Huggett |
| Abstract |
The purpose of this study was to evaluate the steroidogenic effects of sertraline, a popular selective serotonin reuptake inhibitor, on larval fathead minnow (FHM; Pimephales promelas) and adult FHM. Larvae were exposed to 0.1, 1, and 10 µg/L sertraline for 28 days and analyzed for differential mRNA expression of 11β-hydroxysteroid dehydrogenase (11β-HSD), 20β-hydroxysteroid dehydrogenase (20β-HSD), aromatase (CYP19a), nuclear thyroid receptor alpha (TRα), and normalized to RP-L8. Adult FHM were exposed to 3 or 10 µg/L sertraline for 7 days and analyzed for differential expression of the same genes with the addition of thyroid receptor beta (TRβ). Larval FHM exposed to 0.1 μg/L had a significant upregulation of both 20β-HSD and TRα while adult FHM exposed to 10 µg/L had a significant upregulation of 11β-HSD expression in brain tissue. The significance of these findings with respect to survival, growth and reproduction are currently unknown, but represent areas for future research. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 38% |
| Lecturer | 1 | 13% |
| Student > Postgraduate | 1 | 13% |
| Unknown | 3 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 13% |
| Biochemistry, Genetics and Molecular Biology | 1 | 13% |
| Nursing and Health Professions | 1 | 13% |
| Agricultural and Biological Sciences | 1 | 13% |
| Engineering | 1 | 13% |
| Other | 0 | 0% |
| Unknown | 3 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2017.
All research outputs
#16,322,438
of 24,119,703 outputs
Outputs from Bulletin of Environmental Contamination and Toxicology
#2,580
of 4,112 outputs
Outputs of similar age
#197,963
of 313,147 outputs
Outputs of similar age from Bulletin of Environmental Contamination and Toxicology
#9
of 61 outputs
Altmetric has tracked 24,119,703 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,112 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
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We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.