| Title |
HIV-1 infection, response to treatment and establishment of viral latency in a novel humanized T cell-only mouse (TOM) model
|
|---|---|
| Published in |
Retrovirology, October 2013
|
| DOI | 10.1186/1742-4690-10-121 |
| Pubmed ID | |
| Authors |
Jenna B Honeycutt, Angela Wahl, Nancie Archin, Shailesh Choudhary, David Margolis, J Victor Garcia |
| Abstract |
The major targets of HIV infection in humans are CD4⁺ T cells. CD4⁺ T cell depletion is a hallmark of AIDS. Previously, the SCID-hu thy/liv model was used to study the effect of HIV on thymopoeisis in vivo. However, these mice did not develop high levels of peripheral T cell reconstitution and required invasive surgery for infection and analysis. Here, we describe a novel variant of this model in which thy/liv implantation results in systemic reconstitution with human T cells in the absence of any other human hematopoietic lineages. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 55 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 29% |
| Student > Bachelor | 8 | 15% |
| Student > Ph. D. Student | 6 | 11% |
| Professor > Associate Professor | 5 | 9% |
| Student > Master | 4 | 7% |
| Other | 8 | 15% |
| Unknown | 8 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 35% |
| Immunology and Microbiology | 10 | 18% |
| Medicine and Dentistry | 7 | 13% |
| Biochemistry, Genetics and Molecular Biology | 5 | 9% |
| Veterinary Science and Veterinary Medicine | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 10 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2013.
All research outputs
#20,207,295
of 22,727,570 outputs
Outputs from Retrovirology
#1,062
of 1,104 outputs
Outputs of similar age
#184,863
of 211,997 outputs
Outputs of similar age from Retrovirology
#50
of 50 outputs
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