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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s lymphoma
|
|---|---|
| Published in |
Nature Communications, October 2013
|
| DOI | 10.1038/ncomms3549 |
| Pubmed ID | |
| Authors |
Matthew Frampton, Miguel Inacio da Silva Filho, Peter Broderick, Hauke Thomsen, Asta Försti, Jayaram Vijayakrishnan, Rosie Cooke, Victor Enciso-Mora, Per Hoffmann, Markus M. Nöthen, Amy Lloyd, Amy Holroyd, Lewin Eisele, Karl-Heinz Jöckel, Sabine Ponader, Elke Pogge von Strandmann, Tracy Lightfoot, Eve Roman, Annette Lake, Dorothy Montgomery, Ruth F. Jarrett, Anthony J. Swerdlow, Andreas Engert, Kari Hemminki, Richard S. Houlston |
| Abstract |
In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin's lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P=1.14 × 10(-12), odds ratio (OR)=1.26) and 6q23.3 (rs7745098; P=3.42 × 10(-9), OR=1.21). rs3806624 localizes 5' to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with haematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Unknown | 47 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 23% |
| Researcher | 11 | 23% |
| Student > Doctoral Student | 3 | 6% |
| Professor | 3 | 6% |
| Student > Bachelor | 2 | 4% |
| Other | 10 | 21% |
| Unknown | 8 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 25% |
| Agricultural and Biological Sciences | 11 | 23% |
| Biochemistry, Genetics and Molecular Biology | 9 | 19% |
| Chemistry | 2 | 4% |
| Physics and Astronomy | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 10 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2013.
All research outputs
#3,107,672
of 22,727,570 outputs
Outputs from Nature Communications
#28,560
of 46,783 outputs
Outputs of similar age
#30,151
of 212,053 outputs
Outputs of similar age from Nature Communications
#202
of 404 outputs
Altmetric has tracked 22,727,570 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 46,783 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 212,053 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 404 others from the same source and published within six weeks on either side of this one. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.