| Title |
Present state and future perspectives of using pluripotent stem cells in toxicology research
|
|---|---|
| Published in |
Archives of Toxicology, January 2011
|
| DOI | 10.1007/s00204-010-0641-6 |
| Pubmed ID | |
| Authors |
Anna M. Wobus, Peter Löser |
| Abstract |
The use of novel drugs and chemicals requires reliable data on their potential toxic effects on humans. Current test systems are mainly based on animals or in vitro-cultured animal-derived cells and do not or not sufficiently mirror the situation in humans. Therefore, in vitro models based on human pluripotent stem cells (hPSCs) have become an attractive alternative. The article summarizes the characteristics of pluripotent stem cells, including embryonic carcinoma and embryonic germ cells, and discusses the potential of pluripotent stem cells for safety pharmacology and toxicology. Special attention is directed to the potential application of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) for the assessment of developmental toxicology as well as cardio- and hepatotoxicology. With respect to embryotoxicology, recent achievements of the embryonic stem cell test (EST) are described and current limitations as well as prospects of embryotoxicity studies using pluripotent stem cells are discussed. Furthermore, recent efforts to establish hPSC-based cell models for testing cardio- and hepatotoxicity are presented. In this context, methods for differentiation and selection of cardiac and hepatic cells from hPSCs are summarized, requirements and implications with respect to the use of these cells in safety pharmacology and toxicology are presented, and future challenges and perspectives of using hPSCs are discussed. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 192 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 4 | 2% |
| Germany | 3 | 2% |
| United Kingdom | 2 | 1% |
| France | 1 | <1% |
| Hungary | 1 | <1% |
| Netherlands | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 179 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 40 | 21% |
| Researcher | 36 | 19% |
| Student > Bachelor | 29 | 15% |
| Student > Master | 25 | 13% |
| Student > Doctoral Student | 12 | 6% |
| Other | 30 | 16% |
| Unknown | 20 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 78 | 41% |
| Biochemistry, Genetics and Molecular Biology | 31 | 16% |
| Medicine and Dentistry | 22 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 6% |
| Engineering | 7 | 4% |
| Other | 16 | 8% |
| Unknown | 26 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2013.
All research outputs
#6,396,976
of 22,727,570 outputs
Outputs from Archives of Toxicology
#849
of 2,631 outputs
Outputs of similar age
#46,548
of 181,158 outputs
Outputs of similar age from Archives of Toxicology
#3
of 14 outputs
Altmetric has tracked 22,727,570 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 2,631 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 181,158 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.