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miR-139-5p is a regulator of metastatic pathways in breast cancer

Overview of attention for article published in RNA, October 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#44 of 3,052)
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
2 news outlets
blogs
1 blog
twitter
5 X users
patent
1 patent

Citations

dimensions_citation
136 Dimensions

Readers on

mendeley
77 Mendeley
citeulike
1 CiteULike
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Title
miR-139-5p is a regulator of metastatic pathways in breast cancer
Published in
RNA, October 2013
DOI 10.1261/rna.042143.113
Pubmed ID
Authors

Keerthana Krishnan, Anita L. Steptoe, Hilary C. Martin, Diwakar R. Pattabiraman, Katia Nones, Nic Waddell, Mythily Mariasegaram, Peter T. Simpson, Sunil R. Lakhani, Alexander Vlassov, Sean M. Grimmond, Nicole Cloonan

Abstract

Metastasis is a complex, multistep process involved in the progression of cancer from a localized primary tissue to distant sites, often characteristic of the more aggressive forms of this disease. Despite being studied in great detail in recent years, the mechanisms that govern this process remain poorly understood. In this study, we identify a novel role for miR-139-5p in the inhibition of breast cancer progression. We highlight its clinical relevance by reviewing miR-139-5p expression across a wide variety of breast cancer subtypes using in-house generated and online data sets to show that it is most frequently lost in invasive tumors. A biotin pull-down approach was then used to identify the mRNA targets of miR-139-5p in the breast cancer cell line MCF7. Functional enrichment analysis of the pulled-down targets showed significant enrichment of genes in pathways previously implicated in breast cancer metastasis (P < 0.05). Further bioinformatic analysis revealed a predicted disruption to the TGFβ, Wnt, Rho, and MAPK/PI3K signaling cascades, implying a potential role for miR-139-5p in regulating the ability of cells to invade and migrate. To corroborate this finding, using the MDA-MB-231 breast cancer cell line, we show that overexpression of miR-139-5p results in suppression of these cellular phenotypes. Furthermore, we validate the interaction between miR-139-5p and predicted targets involved in these pathways. Collectively, these results suggest a significant functional role for miR-139-5p in breast cancer cell motility and invasion and its potential to be used as a prognostic marker for the aggressive forms of breast cancer.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 1%
Malaysia 1 1%
Italy 1 1%
Australia 1 1%
Denmark 1 1%
Unknown 72 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 23%
Student > Ph. D. Student 17 22%
Student > Master 15 19%
Student > Bachelor 6 8%
Professor > Associate Professor 3 4%
Other 7 9%
Unknown 11 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 35%
Biochemistry, Genetics and Molecular Biology 19 25%
Medicine and Dentistry 14 18%
Computer Science 3 4%
Veterinary Science and Veterinary Medicine 1 1%
Other 2 3%
Unknown 11 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2019.
All research outputs
#1,219,021
of 23,313,051 outputs
Outputs from RNA
#44
of 3,052 outputs
Outputs of similar age
#11,972
of 213,372 outputs
Outputs of similar age from RNA
#2
of 49 outputs
Altmetric has tracked 23,313,051 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,052 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 213,372 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.