Title |
MR Imaging Features of Amyloid-Related Imaging Abnormalities
|
---|---|
Published in |
American Journal of Neuroradiology, April 2013
|
DOI | 10.3174/ajnr.a3500 |
Pubmed ID | |
Authors |
J. Barakos, R. Sperling, S. Salloway, C. Jack, A. Gass, J.B. Fiebach, D. Tampieri, D. Melançon, Y. Miaux, G. Rippon, R. Black, Y. Lu, H.R. Brashear, H.M. Arrighi, K.A. Morris, M. Grundman |
Abstract |
AD is one of the few leading causes of death without a disease-modifying drug; however, hopeful agents are in various phases of development. MR imaging abnormalities, collectively referred to as amyloid-related imaging abnormalities, have been reported for several agents that target cerebral Aβ burden. ARIA includes ARIA-E, parenchymal or sulcal hyperintensities on FLAIR indicative of parenchymal edema or sulcal effusions, and ARIA-H, hypointense regions on gradient recalled-echo/T2* indicative of hemosiderin deposition. This report describes imaging characteristics of ARIA-E and ARIA-H identified during studies of bapineuzumab, a humanized monoclonal antibody against Aβ. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 2 | 2% |
Canada | 2 | 2% |
Switzerland | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 126 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 26 | 20% |
Other | 21 | 16% |
Student > Ph. D. Student | 11 | 8% |
Student > Postgraduate | 11 | 8% |
Professor | 9 | 7% |
Other | 26 | 20% |
Unknown | 29 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 50 | 38% |
Neuroscience | 23 | 17% |
Agricultural and Biological Sciences | 6 | 5% |
Engineering | 5 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
Other | 11 | 8% |
Unknown | 35 | 26% |