| Title |
MicroRNAs Association in the Cardiac Hypertrophy Secondary to Complex Congenital Heart Disease in Children
|
|---|---|
| Published in |
Pediatric Cardiology, April 2017
|
| DOI | 10.1007/s00246-017-1607-8 |
| Pubmed ID | |
| Authors |
Ma. C. Sánchez-Gómez, K. A. García-Mejía, M. Pérez-Díaz Conti, G. Díaz-Rosas, I. Palma-Lara, R. Sánchez-Urbina, M. Klünder-Klünder, J. A. Botello-Flores, N. A. Balderrábano- Saucedo, A. Contreras-Ramos |
| Abstract |
Complex congenital heart disease (CHD) affects cardiac blood flow, generating a pressure overload in the compromised ventricles and provoking hypertrophy that over time will induce myocardial dysfunction and cause a potential risk of imminent death. Therefore, the early diagnosis of complex CHD is paramount during the first year of life, with surgical treatment of patients favoring survival. In the present study, we analyzed cardiac tissue and plasma of children with cardiac hypertrophy (CH) secondary to CHD for the expression of 11 miRNAs specific to CH in adults. The results were compared with the miRNA expression patterns in tissue and blood of healthy children. In this way, we determined that miRNAs 1, 18b, 21, 23b, 133a, 195, and 208b constitute the expression profile of the cardiac tissue of children with CHD. Meanwhile, miRNAs 21, 23a, 23b, and 24 can be considered specific biomarkers for the diagnosis of CH in infants with CHD. These results suggest that CH secondary to CHD in children differs in its mechanism from that described for adult hypertrophy, offering a new perspective to study the development of this pathology and to determine the potential of hypertrophic miRNAs to be biomarkers for early CH. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
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| Country | Count | As % |
|---|---|---|
| Unknown | 21 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 29% |
| Student > Bachelor | 4 | 19% |
| Other | 1 | 5% |
| Student > Doctoral Student | 1 | 5% |
| Librarian | 1 | 5% |
| Other | 4 | 19% |
| Unknown | 4 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 29% |
| Biochemistry, Genetics and Molecular Biology | 3 | 14% |
| Agricultural and Biological Sciences | 2 | 10% |
| Immunology and Microbiology | 1 | 5% |
| Unspecified | 1 | 5% |
| Other | 2 | 10% |
| Unknown | 6 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2017.
All research outputs
#20,413,129
of 22,963,381 outputs
Outputs from Pediatric Cardiology
#1,101
of 1,412 outputs
Outputs of similar age
#269,833
of 309,562 outputs
Outputs of similar age from Pediatric Cardiology
#17
of 26 outputs
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