Title |
Insulin inhibits leptin receptor signalling in HEK293 cells at the level of janus kinase-2: a potential mechanism for hyperinsulinaemia-associated leptin resistance
|
---|---|
Published in |
Diabetologia, September 2001
|
DOI | 10.1007/s001250100614 |
Pubmed ID | |
Authors |
M. Kellerer, R. Lammers, A. Fritsche, V. Strack, F. Machicao, P. Borboni, A. Ullrich, H. U. Häring |
Abstract |
Leptin resistance in obese humans seems to be predominantly caused by signalling abnormalities at the post receptor level. Leptin resistance in obese individuals is frequently associated with insulin resistance and pronounced hyperinsulinaemia indicating a negative crosstalk of the insulin and leptin signalling chain. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 7 | 33% |
Chile | 2 | 10% |
Spain | 1 | 5% |
Vanuatu | 1 | 5% |
Unknown | 10 | 48% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 21 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
United States | 1 | 2% |
Netherlands | 1 | 2% |
Sweden | 1 | 2% |
Unknown | 41 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 27% |
Student > Ph. D. Student | 9 | 20% |
Student > Master | 6 | 13% |
Student > Bachelor | 4 | 9% |
Professor | 2 | 4% |
Other | 5 | 11% |
Unknown | 7 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 13 | 29% |
Medicine and Dentistry | 9 | 20% |
Biochemistry, Genetics and Molecular Biology | 7 | 16% |
Neuroscience | 5 | 11% |
Social Sciences | 1 | 2% |
Other | 1 | 2% |
Unknown | 9 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 February 2021.
All research outputs
#1,399,444
of 25,646,963 outputs
Outputs from Diabetologia
#750
of 5,368 outputs
Outputs of similar age
#969
of 41,028 outputs
Outputs of similar age from Diabetologia
#2
of 25 outputs
Altmetric has tracked 25,646,963 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,368 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.8. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 41,028 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.