| Title |
Reduced Gyral Window and Corpus Callosum Size in Autism: Possible Macroscopic Correlates of a Minicolumnopathy
|
|---|---|
| Published in |
Journal of Autism and Developmental Disorders, January 2009
|
| DOI | 10.1007/s10803-008-0681-4 |
| Pubmed ID | |
| Authors |
Manuel F. Casanova, Ayman El-Baz, Meghan Mott, Glenn Mannheim, Hossam Hassan, Rachid Fahmi, Jay Giedd, Judith M. Rumsey, Andrew E. Switala, Aly Farag |
| Abstract |
Minicolumnar changes that generalize throughout a significant portion of the cortex have macroscopic structural correlates that may be visualized with modern structural neuroimaging techniques. In magnetic resonance images (MRIs) of fourteen autistic patients and 28 controls, the present study found macroscopic morphological correlates to recent neuropathological findings suggesting a minicolumnopathy in autism. Autistic patients manifested a significant reduction in the aperture for afferent/efferent cortical connections, i.e., gyral window. Furthermore, the size of the gyral window directly correlated to the size of the corpus callosum. A reduced gyral window constrains the possible size of projection fibers and biases connectivity towards shorter corticocortical fibers at the expense of longer association/commisural fibers. The findings may help explain abnormalities in motor skill development, differences in postnatal brain growth, and the regression of acquired functions observed in some autistic patients. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 2 | 2% |
| Germany | 1 | 1% |
| Mexico | 1 | 1% |
| Japan | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 88 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 23% |
| Researcher | 17 | 18% |
| Student > Master | 8 | 9% |
| Professor | 8 | 9% |
| Student > Bachelor | 8 | 9% |
| Other | 21 | 22% |
| Unknown | 10 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 22 | 23% |
| Medicine and Dentistry | 21 | 22% |
| Neuroscience | 10 | 11% |
| Agricultural and Biological Sciences | 9 | 10% |
| Engineering | 6 | 6% |
| Other | 10 | 11% |
| Unknown | 16 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2023.
All research outputs
#4,044,680
of 23,915,168 outputs
Outputs from Journal of Autism and Developmental Disorders
#1,684
of 5,283 outputs
Outputs of similar age
#22,722
of 176,102 outputs
Outputs of similar age from Journal of Autism and Developmental Disorders
#7
of 22 outputs
Altmetric has tracked 23,915,168 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,283 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.3. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 176,102 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.