| Title |
Shaping the cellular landscape with Set2/SETD2 methylation
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, April 2017
|
| DOI | 10.1007/s00018-017-2517-x |
| Pubmed ID | |
| Authors |
Stephen L. McDaniel, Brian D. Strahl |
| Abstract |
Chromatin structure is a major barrier to gene transcription that must be disrupted and re-set during each round of transcription. Central to this process is the Set2/SETD2 methyltransferase that mediates co-transcriptional methylation to histone H3 at lysine 36 (H3K36me). Studies reveal that H3K36me not only prevents inappropriate transcriptional initiation from arising within gene bodies, but that it has other conserved functions that include the repair of damaged DNA and regulation of pre-mRNA splicing. Consistent with the importance of Set2/SETD2 in chromatin biology, mutations of SETD2, or mutations at or near H3K36 in H3.3, have recently been found to underlie cancer development. This review will summarize the latest insights into the functions of Set2/SETD2 in genome regulation and cancer development. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 151 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Austria | 1 | <1% |
| Unknown | 149 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 49 | 32% |
| Researcher | 17 | 11% |
| Student > Master | 15 | 10% |
| Student > Bachelor | 8 | 5% |
| Student > Doctoral Student | 7 | 5% |
| Other | 20 | 13% |
| Unknown | 35 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 70 | 46% |
| Agricultural and Biological Sciences | 29 | 19% |
| Medicine and Dentistry | 7 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Immunology and Microbiology | 2 | 1% |
| Other | 4 | 3% |
| Unknown | 36 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2017.
All research outputs
#18,530,416
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#3,334
of 4,151 outputs
Outputs of similar age
#223,145
of 310,996 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#33
of 48 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,996 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.