| Title |
Dreamlike effects of LSD on waking imagery in humans depend on serotonin 2A receptor activation
|
|---|---|
| Published in |
Psychopharmacology, April 2017
|
| DOI | 10.1007/s00213-017-4610-0 |
| Pubmed ID | |
| Authors |
Rainer Kraehenmann, Dan Pokorny, Leonie Vollenweider, Katrin H. Preller, Thomas Pokorny, Erich Seifritz, Franz X. Vollenweider |
| Abstract |
Accumulating evidence indicates that the mixed serotonin and dopamine receptor agonist lysergic acid diethylamide (LSD) induces an altered state of consciousness that resembles dreaming. This study aimed to test the hypotheses that LSD produces dreamlike waking imagery and that this imagery depends on 5-HT2A receptor activation and is related to subjective drug effects. Twenty-five healthy subjects performed an audiorecorded guided mental imagery task 7 h after drug administration during three drug conditions: placebo, LSD (100 mcg orally) and LSD together with the 5-HT2A receptor antagonist ketanserin (40 mg orally). Cognitive bizarreness of guided mental imagery reports was quantified as a standardised formal measure of dream mentation. State of consciousness was evaluated using the Altered State of Consciousness (5D-ASC) questionnaire. LSD, compared with placebo, significantly increased cognitive bizarreness (p < 0.001). The LSD-induced increase in cognitive bizarreness was positively correlated with the LSD-induced loss of self-boundaries and cognitive control (p < 0.05). Both LSD-induced increases in cognitive bizarreness and changes in state of consciousness were fully blocked by ketanserin. LSD produced mental imagery similar to dreaming, primarily via activation of the 5-HT2A receptor and in relation to loss of self-boundaries and cognitive control. Future psychopharmacological studies should assess the differential contribution of the D2/D1 and 5-HT1A receptors to cognitive bizarreness. |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 13% |
| Italy | 1 | 7% |
| Netherlands | 1 | 7% |
| United States | 1 | 7% |
| United Kingdom | 1 | 7% |
| Unknown | 9 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 87% |
| Scientists | 2 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 210 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 208 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 44 | 21% |
| Student > Ph. D. Student | 25 | 12% |
| Researcher | 23 | 11% |
| Student > Master | 23 | 11% |
| Student > Doctoral Student | 15 | 7% |
| Other | 25 | 12% |
| Unknown | 55 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 40 | 19% |
| Neuroscience | 38 | 18% |
| Medicine and Dentistry | 17 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 13 | 6% |
| Biochemistry, Genetics and Molecular Biology | 8 | 4% |
| Other | 35 | 17% |
| Unknown | 59 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 47. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2024.
All research outputs
#811,769
of 23,957,285 outputs
Outputs from Psychopharmacology
#205
of 5,456 outputs
Outputs of similar age
#17,657
of 312,899 outputs
Outputs of similar age from Psychopharmacology
#5
of 58 outputs
Altmetric has tracked 23,957,285 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,456 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.1. This one has done particularly well, scoring higher than 96% of its peers.
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We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.