Title |
HIV–Mycobacterium tuberculosis co‐infection: a ‘danger‐couple model’ of disease pathogenesis
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Published in |
Pathogens and Disease, November 2013
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DOI | 10.1111/2049-632x.12108 |
Pubmed ID | |
Authors |
Esaki M. Shankar, Ramachandran Vignesh, Rada Ellegård, Muttiah Barathan, Yee K. Chong, M. Kahar Bador, Devi V. Rukumani, Negar S. Sabet, Adeeba Kamarulzaman, Vijayakumar Velu, Marie Larsson |
Abstract |
Tuberculosis (TB) and human immunodeficiency virus (HIV) infection interfere and impact the pathogenesis phenomena of each other. Owing to atypical clinical presentations and diagnostic complications, HIV/TB co-infection continues to be a menace for healthcare providers. Although the increased access to highly active antiretroviral therapy (HAART) has led to a reduction in HIV-associated opportunistic infections and mortality, the concurrent management of HIV/TB co-infection remains a challenge owing to adverse effects, complex drug interactions, overlapping toxicities and tuberculosis -associated immune reconstitution inflammatory syndrome. Several hypotheses have been put forward for the exacerbation of tuberculosis by HIV and vice versa supported by immunological studies. Discussion on the mechanisms produced by infectious cofactors with impact on disease pathology could shed light on how to design potential interventions that could decelerate disease progression. With no vaccine for HIV and lack of an effective vaccine for tuberculosis, it is essential to design strategies against HIV-TB co-infection. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | <1% |
Netherlands | 1 | <1% |
South Africa | 1 | <1% |
Unknown | 229 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 43 | 19% |
Student > Bachelor | 38 | 16% |
Student > Ph. D. Student | 28 | 12% |
Researcher | 20 | 9% |
Student > Doctoral Student | 17 | 7% |
Other | 37 | 16% |
Unknown | 49 | 21% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 65 | 28% |
Agricultural and Biological Sciences | 36 | 16% |
Immunology and Microbiology | 22 | 9% |
Biochemistry, Genetics and Molecular Biology | 14 | 6% |
Nursing and Health Professions | 10 | 4% |
Other | 32 | 14% |
Unknown | 53 | 23% |