| Title |
Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells
|
|---|---|
| Published in |
Diabetologia, October 2013
|
| DOI | 10.1007/s00125-013-3083-x |
| Pubmed ID | |
| Authors |
Gemma L. Pearson, Natalie Mellett, Kwan Yi Chu, James Cantley, Aimee Davenport, Pauline Bourbon, Casey C. Cosner, Paul Helquist, Peter J. Meikle, Trevor J. Biden |
| Abstract |
Lipolytic breakdown of endogenous lipid pools in pancreatic beta cells contributes to glucose-stimulated insulin secretion (GSIS) and is thought to be mediated by acute activation of neutral lipases in the amplification pathway. Recently it has been shown in other cell types that endogenous lipid can be metabolised by autophagy, and this lipophagy is catalysed by lysosomal acid lipase (LAL). This study aimed to elucidate a role for LAL and lipophagy in pancreatic beta cells. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 4% |
| Mexico | 2 | 4% |
| Singapore | 1 | 2% |
| Austria | 1 | 2% |
| Unknown | 50 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 27% |
| Student > Ph. D. Student | 14 | 25% |
| Other | 6 | 11% |
| Student > Bachelor | 3 | 5% |
| Professor | 3 | 5% |
| Other | 8 | 14% |
| Unknown | 7 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 29% |
| Biochemistry, Genetics and Molecular Biology | 15 | 27% |
| Medicine and Dentistry | 12 | 21% |
| Chemistry | 3 | 5% |
| Immunology and Microbiology | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 6 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2013.
All research outputs
#1,050,237
of 22,727,570 outputs
Outputs from Diabetologia
#587
of 5,032 outputs
Outputs of similar age
#10,540
of 212,101 outputs
Outputs of similar age from Diabetologia
#10
of 51 outputs
Altmetric has tracked 22,727,570 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,032 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.6. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 212,101 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.