| Title |
Intervening Sequences of Regularly Spaced Prokaryotic Repeats Derive from Foreign Genetic Elements
|
|---|---|
| Published in |
Journal of Molecular Evolution, February 2005
|
| DOI | 10.1007/s00239-004-0046-3 |
| Pubmed ID | |
| Authors |
Francisco J.M. Mojica, Chc)sar Díez-Villaseñor, Jesús García-Martínez, Elena Soria |
| Abstract |
Prokaryotes contain short DN repeats known as CRISPR, recognizable by the regular spacing existing between the recurring units. They represent the most widely distributed family of repeats among prokaryotic genomes suggesting a biological function. The origin of the intervening sequences, at present unknown, could provide clues about their biological activities. Here we show that CRISPR spacers derive from preexisting sequences, either chromosomal or within transmissible genetic elements such as bacteriophages and conjugative plasmids. Remarkably, these extrachromosomal elements fail to infect the specific spacer-carrier strain, implying a relationship between CRISPR and immunity against targeted DNA. Bacteriophages and conjugative plasmids are involved in prokaryotic population control, evolution, and pathogenicity. All these biological traits could be influenced by the presence of specific spacers. CRISPR loci can be visualized as mosaics of a repeated unit, separated by sequences at some time present elsewhere in the cell. |
X Demographics
The data shown below were collected from the profiles of 41 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 9 | 22% |
| United States | 6 | 15% |
| India | 2 | 5% |
| United Kingdom | 2 | 5% |
| Sweden | 2 | 5% |
| Australia | 1 | 2% |
| Canada | 1 | 2% |
| Côte d'Ivoire | 1 | 2% |
| Colombia | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 16 | 39% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 24 | 59% |
| Scientists | 16 | 39% |
| Practitioners (doctors, other healthcare professionals) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 3,489 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | <1% |
| Spain | 4 | <1% |
| Brazil | 3 | <1% |
| Germany | 3 | <1% |
| Denmark | 2 | <1% |
| Japan | 2 | <1% |
| United Kingdom | 2 | <1% |
| Australia | 1 | <1% |
| New Zealand | 1 | <1% |
| Other | 6 | <1% |
| Unknown | 3456 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 814 | 23% |
| Student > Master | 561 | 16% |
| Student > Ph. D. Student | 558 | 16% |
| Researcher | 250 | 7% |
| Student > Doctoral Student | 139 | 4% |
| Other | 325 | 9% |
| Unknown | 842 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 1261 | 36% |
| Agricultural and Biological Sciences | 766 | 22% |
| Immunology and Microbiology | 120 | 3% |
| Medicine and Dentistry | 92 | 3% |
| Engineering | 61 | 2% |
| Other | 274 | 8% |
| Unknown | 915 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 284. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2024.
All research outputs
#126,516
of 25,837,817 outputs
Outputs from Journal of Molecular Evolution
#2
of 1,502 outputs
Outputs of similar age
#144
of 161,436 outputs
Outputs of similar age from Journal of Molecular Evolution
#1
of 13 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,502 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.