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Different T cell memory in preadolescents after whole-cell or acellular pertussis vaccination

Overview of attention for article published in Vaccine, October 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

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1 news outlet
blogs
1 blog
policy
1 policy source
twitter
5 X users

Citations

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56 Dimensions

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69 Mendeley
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Title
Different T cell memory in preadolescents after whole-cell or acellular pertussis vaccination
Published in
Vaccine, October 2013
DOI 10.1016/j.vaccine.2013.10.056
Pubmed ID
Authors

Kaatje Smits, Gaelle Pottier, Julie Smet, Violette Dirix, Françoise Vermeulen, Iris De Schutter, Maria Carollo, Camille Locht, Clara Maria Ausiello, Françoise Mascart

Abstract

To better understand vaccine-induced protection and its potential failure in light of recent whooping cough resurgence, we evaluated quantity as well as quality of memory T cell responses in B. pertussis-vaccinated preadolescent children. Using a technique based on flow cytometry to detect proliferation, cytokine production and phenotype of antigen-specific cells, we evaluated residual T cell memory in a cohort of preadolescents who received a whole-cell pertussis (wP; n=11) or an acellular pertussis vaccine (aP; n=13) during infancy, and with a median of 4 years elapsed from the last pertussis booster vaccine, which was aP for all children. We demonstrated that B. pertussis-specific memory T cells are detectable in the majority of preadolescent children several years after vaccination. CD4(+) and CD8(+) T cell proliferation in response to pertussis toxin and/or filamentous hemagglutinin was detected in 79% and 60% of the children respectively, and interferon-γ or tumor necrosis factor-α producing CD4(+) T cells were detected in 65% and 53% of the children respectively. Phenotyping of the responding cells showed that the majority of antigen-specific cells, whether defined by proliferation or cytokine production, were CD45RA(-)CCR7(-) effector memory T cells. Although the time since the last booster vaccine was significantly longer for wP-compared to aP-vaccinated children, their proliferation capacity in response to antigenic stimulation was comparable, and more children had a detectable cytokine response after wP- compared to aP-vaccination. This study supports at the immunological level recent epidemiological studies indicating that infant vaccination with wP induces longer lasting immunity than vaccination with aP-vaccines.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 2 3%
United Kingdom 1 1%
Unknown 66 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 22%
Student > Ph. D. Student 11 16%
Student > Bachelor 9 13%
Student > Master 7 10%
Professor > Associate Professor 4 6%
Other 11 16%
Unknown 12 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 25%
Immunology and Microbiology 13 19%
Medicine and Dentistry 12 17%
Biochemistry, Genetics and Molecular Biology 5 7%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Other 6 9%
Unknown 13 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 July 2018.
All research outputs
#1,864,228
of 25,373,627 outputs
Outputs from Vaccine
#1,553
of 16,509 outputs
Outputs of similar age
#17,119
of 225,432 outputs
Outputs of similar age from Vaccine
#24
of 180 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 16,509 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.7. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 225,432 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 180 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.