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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Drugs, genes and the blues: Pharmacogenetics of the antidepressant response from mouse to man
|
|---|---|
| Published in |
Pharmacology, Biochemistry & Behavior, October 2013
|
| DOI | 10.1016/j.pbb.2013.10.015 |
| Pubmed ID | |
| Authors |
Olivia F. O'Leary, Fionn E. O'Brien, Richard M. O'Connor, John F. Cryan |
| Abstract |
While antidepressant drugs are beneficial to many patients, current treatments for depression remain sub-optimal. Up to half of patients with a major depressive episode fail to achieve remission with a first line antidepressant treatment. Identification of the molecular mechanisms that dictate whether a patient will successfully respond to a particular antidepressant treatment while tolerating its side-effects is not only a major challenge in biological psychiatry research but is also one that shows great promise. This review summarises data from both clinical and preclinical studies that point to a role of specific genes in the response and resistance to antidepressant therapeutics. Moreover, we discuss how such findings have increased our understanding of the mechanism of action of antidepressant drugs. Finally, we comment on how this information may potentially influence the future development of personalised medicine approaches for the treatment of depression. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 1 | 14% |
| United States | 1 | 14% |
| Canada | 1 | 14% |
| United Kingdom | 1 | 14% |
| Unknown | 3 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 71% |
| Scientists | 2 | 29% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 1% |
| Germany | 1 | 1% |
| Ireland | 1 | 1% |
| Lithuania | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 66 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 17% |
| Student > Master | 11 | 15% |
| Student > Bachelor | 10 | 14% |
| Researcher | 9 | 13% |
| Student > Doctoral Student | 5 | 7% |
| Other | 16 | 23% |
| Unknown | 8 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 11 | 15% |
| Medicine and Dentistry | 11 | 15% |
| Agricultural and Biological Sciences | 9 | 13% |
| Neuroscience | 7 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 10% |
| Other | 15 | 21% |
| Unknown | 11 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 October 2013.
All research outputs
#6,529,257
of 25,374,917 outputs
Outputs from Pharmacology, Biochemistry & Behavior
#870
of 3,159 outputs
Outputs of similar age
#55,247
of 224,524 outputs
Outputs of similar age from Pharmacology, Biochemistry & Behavior
#21
of 43 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 3,159 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 224,524 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.