| Title |
Glycogen Synthase Kinase 3 Beta (GSK3β) at the Tip of Neuronal Development and Regeneration
|
|---|---|
| Published in |
Molecular Neurobiology, October 2013
|
| DOI | 10.1007/s12035-013-8571-y |
| Pubmed ID | |
| Authors |
Oscar Seira, José Antonio del Río |
| Abstract |
Gaining a basic understanding of the inhibitory molecules and the intracellular signaling involved in axon development and repulsion after neural lesions is of clear biomedical interest. In recent years, numerous studies have described new molecules and intracellular mechanisms that impair axonal outgrowth after injury. In this scenario, the role of glycogen synthase kinase 3 beta (GSK3β) in the axonal responses that occur after central nervous system (CNS) lesions began to be elucidated. GSK3β function in the nervous tissue is associated with neural development, neuron polarization, and, more recently, neurodegeneration. In fact, GSK3β has been considered as a putative therapeutic target for promoting functional recovery in injured or degenerative CNS. In this review, we summarize current understanding of the role of GSK3β during neuronal development and regeneration. In particular, we discuss GSK3β activity levels and their possible impact on cytoskeleton dynamics during both processes. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Croatia | 1 | 1% |
| India | 1 | 1% |
| Unknown | 87 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 29% |
| Researcher | 13 | 15% |
| Student > Bachelor | 10 | 11% |
| Student > Postgraduate | 10 | 11% |
| Professor > Associate Professor | 6 | 7% |
| Other | 14 | 16% |
| Unknown | 10 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 26 | 29% |
| Agricultural and Biological Sciences | 21 | 24% |
| Biochemistry, Genetics and Molecular Biology | 18 | 20% |
| Medicine and Dentistry | 4 | 4% |
| Immunology and Microbiology | 2 | 2% |
| Other | 6 | 7% |
| Unknown | 12 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2014.
All research outputs
#6,396,976
of 22,729,647 outputs
Outputs from Molecular Neurobiology
#1,216
of 3,434 outputs
Outputs of similar age
#59,007
of 211,943 outputs
Outputs of similar age from Molecular Neurobiology
#6
of 25 outputs
Altmetric has tracked 22,729,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 3,434 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 211,943 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.