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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A Population-Based Study of Genetic Variation and Psychotic Experiences in Adolescents
|
|---|---|
| Published in |
Schizophrenia Bulletin, October 2013
|
| DOI | 10.1093/schbul/sbt146 |
| Pubmed ID | |
| Authors |
Stanley Zammit, Marian Hamshere, Sarah Dwyer, Lyudmila Georgiva, Nic Timpson, Valentina Moskvina, Alexander Richards, David M Evans, Glyn Lewis, Peter Jones, Michael J. Owen, Michael C. O’Donovan |
| Abstract |
Psychotic experiences are not uncommon in general population samples, but no studies have examined to what extent confirmed risk variants for schizophrenia are associated with such experiences. A total of 3483 children in a birth cohort study participated in semistructured interviews for psychotic experiences at ages 12 and 18. We examined whether (1) a composite measure of risk for schizophrenia conferred by common alleles (polygenic score) was associated with psychotic experiences, (2) variants with genome-wide evidence for association with schizophrenia were associated with psychotic experiences, and (3) we could identify genetic variants for psychotic experiences using a genome-wide association (GWA) approach. We found no evidence that a schizophrenia polygenic score, or variants showing genome-wide evidence of association with schizophrenia, were associated with adolescent psychotic experiences within the general population. In fact, individuals who had a higher number of risk alleles for genome-wide hits for schizophrenia showed a decreased risk of psychotic experiences. In the GWA study, no variants showed GWA for psychotic experiences, and there was no evidence that the strongest hits (P < 5 × 10(-5)) were enriched for variants associated with schizophrenia in large consortia. Although polygenic scores are weak tools for prediction of schizophrenia, they show strong evidence of association with this disorder. Our findings, however, lend little support to the hypothesis that psychotic experiences in population-based samples of adolescents share a comparable genetic architecture to schizophrenia, or that utilizing a broader and more common phenotype of psychotic experiences will be an efficient approach to increase understanding of the genetic etiology of schizophrenia. |
X Demographics
The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 6 | 32% |
| United States | 2 | 11% |
| Côte d'Ivoire | 1 | 5% |
| Ireland | 1 | 5% |
| Unknown | 9 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 58% |
| Scientists | 6 | 32% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
| Practitioners (doctors, other healthcare professionals) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Hong Kong | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 106 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 28% |
| Researcher | 16 | 15% |
| Student > Postgraduate | 12 | 11% |
| Student > Bachelor | 11 | 10% |
| Student > Master | 11 | 10% |
| Other | 17 | 16% |
| Unknown | 12 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 35 | 32% |
| Medicine and Dentistry | 21 | 19% |
| Agricultural and Biological Sciences | 14 | 13% |
| Biochemistry, Genetics and Molecular Biology | 8 | 7% |
| Neuroscience | 4 | 4% |
| Other | 10 | 9% |
| Unknown | 17 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2014.
All research outputs
#1,443,356
of 25,632,496 outputs
Outputs from Schizophrenia Bulletin
#326
of 3,241 outputs
Outputs of similar age
#13,051
of 226,161 outputs
Outputs of similar age from Schizophrenia Bulletin
#5
of 40 outputs
Altmetric has tracked 25,632,496 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,241 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.9. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,161 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.