| Title |
Gap-junctional channel and hemichannel activity of two recently identified connexin 26 mutants associated with deafness
|
|---|---|
| Published in |
Pflügers Archiv - European Journal of Physiology, January 2016
|
| DOI | 10.1007/s00424-016-1788-7 |
| Pubmed ID | |
| Authors |
Viviana Dalamon, Mariana C. Fiori, Vania A. Figueroa, Carolina A. Oliva, Rodrigo del Rio, Wendy Gonzalez, Jonathan Canan, Ana B. Elgoyhen, Guillermo A. Altenberg, Mauricio A. Retamal |
| Abstract |
Gap-junction channels (GJCs) are formed by head-to-head association of two hemichannels (HCs, connexin hexamers). HCs and GJCs are permeable to ions and hydrophilic molecules of up to Mr ~1 kDa. Hearing impairment of genetic origin is common, and mutations of connexin 26 (Cx26) are its major cause. We recently identified two novel Cx26 mutations in hearing-impaired subjects, L10P and G109V. L10P forms functional GJCs with slightly altered voltage dependence and HCs with decrease ATP/cationic dye selectivity. G109V does not form functional GJCs, but forms functional HCs with enhanced extracellular Ca(2+) sensitivity and subtle alterations in voltage dependence and ATP/cationic dye selectivity. Deafness associated with G109V could result from decreased GJCs activity, whereas deafness associated to L10P may have a more complex mechanism that involves changes in HC permeability. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 21 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 19% |
| Unspecified | 3 | 14% |
| Student > Bachelor | 3 | 14% |
| Student > Ph. D. Student | 3 | 14% |
| Professor | 2 | 10% |
| Other | 3 | 14% |
| Unknown | 3 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 4 | 19% |
| Biochemistry, Genetics and Molecular Biology | 4 | 19% |
| Unspecified | 3 | 14% |
| Neuroscience | 3 | 14% |
| Medicine and Dentistry | 3 | 14% |
| Other | 0 | 0% |
| Unknown | 4 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2017.
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#21,164,509
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Outputs from Pflügers Archiv - European Journal of Physiology
#1,798
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#336,458
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Outputs of similar age from Pflügers Archiv - European Journal of Physiology
#23
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