↓ Skip to main content

Alterations of Hippocampal Glucose Metabolism by Even versus Uneven Medium Chain Triglycerides

Overview of attention for article published in Cerebrovascular and Brain Metabolism Reviews, October 2013
Altmetric Badge

Mentioned by

twitter
2 X users

Citations

dimensions_citation
31 Dimensions

Readers on

mendeley
62 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Alterations of Hippocampal Glucose Metabolism by Even versus Uneven Medium Chain Triglycerides
Published in
Cerebrovascular and Brain Metabolism Reviews, October 2013
DOI 10.1038/jcbfm.2013.184
Pubmed ID
Authors

Tanya S McDonald, Kah Ni Tan, Mark P Hodson, Karin Borges

Abstract

Medium chain triglycerides (MCTs) are used to treat neurologic disorders with metabolic impairments, including childhood epilepsy and early Alzheimer's disease. However, the metabolic effects of MCTs in the brain are still unclear. Here, we studied the effects of feeding even and uneven MCTs on brain glucose metabolism in the mouse. Adult mice were fed 35% (calories) of trioctanoin or triheptanoin (the triglycerides of octanoate or heptanoate, respectively) or a matching control diet for 3 weeks. Enzymatic assays and targeted metabolomics by liquid chromatography tandem mass spectrometry were used to quantify metabolites in extracts from the hippocampal formations (HFs). Both oils increased the levels of β-hydroxybutyrate, but no other significant metabolic alterations were observed after triheptanoin feeding. The levels of glucose 6-phosphate and fructose 6-phosphate were increased in the HF of mice fed trioctanoin, whereas levels of metabolites further downstream in the glycolytic pathway and the pentose phosphate pathway were reduced. This indicates that trioctanoin reduces glucose utilization because of a decrease in phosphofructokinase activity. Trioctanoin and triheptanoin showed similar anticonvulsant effects in the 6 Hz seizure model, but it remains unknown to what extent the anticonvulsant mechanism(s) are shared. In conclusion, triheptanoin unlike trioctanoin appears to not alter glucose metabolism in the healthy brain.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 62 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 21%
Student > Master 13 21%
Student > Bachelor 10 16%
Researcher 9 15%
Student > Doctoral Student 3 5%
Other 8 13%
Unknown 6 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 32%
Medicine and Dentistry 11 18%
Neuroscience 10 16%
Biochemistry, Genetics and Molecular Biology 6 10%
Nursing and Health Professions 2 3%
Other 10 16%
Unknown 3 5%