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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cks confers specificity to phosphorylation-dependent CDK signaling pathways
|
|---|---|
| Published in |
Nature Structural & Molecular Biology, November 2013
|
| DOI | 10.1038/nsmb.2707 |
| Pubmed ID | |
| Authors |
Denise A McGrath, Eva Rose M Balog, Mardo Kõivomägi, Rafael Lucena, Michelle V Mai, Alexander Hirschi, Douglas R Kellogg, Mart Loog, Seth M Rubin |
| Abstract |
Cks is an evolutionarily conserved protein that regulates cyclin-dependent kinase (CDK) activity. Clarifying the underlying mechanisms and cellular contexts of Cks function is critical because Cks is essential for proper cell growth, and its overexpression has been linked to cancer. We observe that budding-yeast Cks associates with select phosphorylated sequences in cell cycle-regulatory proteins. We characterize the molecular interactions responsible for this specificity and demonstrate that Cks enhances CDK activity in response to specific priming phosphosites. Identification of the binding consensus sequence allows us to identify putative Cks-directed CDK substrates and binding partners. We characterize new Cks-binding sites in the mitotic regulator Wee1 and discover a new role for Cks in regulating CDK activity at mitotic entry. Together, our results portray Cks as a multifunctional phosphoadaptor that serves as a specificity factor for CDK activity. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 122 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| United States | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 118 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 25% |
| Researcher | 21 | 17% |
| Student > Bachelor | 16 | 13% |
| Student > Master | 15 | 12% |
| Professor > Associate Professor | 4 | 3% |
| Other | 9 | 7% |
| Unknown | 27 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 43 | 35% |
| Biochemistry, Genetics and Molecular Biology | 36 | 30% |
| Chemistry | 10 | 8% |
| Medicine and Dentistry | 3 | 2% |
| Physics and Astronomy | 2 | 2% |
| Other | 3 | 2% |
| Unknown | 25 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2013.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Nature Structural & Molecular Biology
#3,943
of 4,186 outputs
Outputs of similar age
#171,253
of 227,360 outputs
Outputs of similar age from Nature Structural & Molecular Biology
#40
of 45 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,186 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.5. This one is in the 2nd percentile – i.e., 2% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,360 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.