Title |
Accuracy of coronary computed tomography angiography for bioresorbable scaffold luminal investigation: a comparison with optical coherence tomography
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Published in |
The International Journal of Cardiovascular Imaging, November 2016
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DOI | 10.1007/s10554-016-1018-6 |
Pubmed ID | |
Authors |
Carlos Collet, Yohei Sotomi, Rafael Cavalcante, Taku Asano, Yosuke Miyazaki, Erhan Tenekecioglu, Pieter Kistlaar, Yaping Zeng, Pannipa Suwanasson, Robbert J. de Winter, Koen Nieman, Patrick W. Serruys, Yoshinobu Onuma |
Abstract |
To establish the accuracy of coronary computed tomography angiography (CTA) for in-scaffold quantitative evaluation with optical coherence tomography (OCT) as a reference. The translucent backbone of the bioresorbable scaffold allow us to evaluate non-invasively the coronary lumen with coronary CTA. In the ABSORB first-in-man studies, coronary CTA was shown to be feasible for quantitative luminal assessment. Nevertheless, a comparison with an intravascular modality with higher resolution has never been performed. In the ABSORB Cohort B trial, 101 patient with non-complex lesions were treated with the fully biodegradable vascular scaffold. For this analysis, all patients who underwent coronary CTA at 18 months and OCT within ±180 days were included. Coronary CTA and OCT data were analysed at an independent core laboratory for quantitative cross-sectional luminal dimensions. The primary objective was the accuracy and precision of coronary CTA for in-scaffold minimal lumen area assessment, with OCT as a reference. Among the 101 patients of the ABSORB Cohort B trial, 35 underwent both OCT and coronary CTA. The feasibility of quantitative evaluation was 74%. In the scaffolded segment, coronary CTA underestimated minimal lumen area by 9.8% (accuracy 0.39 mm(2), precision 1.0 mm(2), 95% limits of agreement -1.71 to 2.50 mm(2)). A similar level of agreement was observed in the non-scaffolded segment. Compared to OCT, coronary CTA appears to be accurate for the estimation of in-scaffold luminal areas, with no difference compared to the non-scaffolded region. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 5 | 16% |
Researcher | 4 | 13% |
Student > Bachelor | 3 | 10% |
Student > Master | 3 | 10% |
Student > Ph. D. Student | 2 | 6% |
Other | 3 | 10% |
Unknown | 11 | 35% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
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Neuroscience | 1 | 3% |
Other | 1 | 3% |
Unknown | 13 | 42% |