| Title |
The islet endothelial cell: a novel contributor to beta cell secretory dysfunction in diabetes
|
|---|---|
| Published in |
Diabetologia, April 2017
|
| DOI | 10.1007/s00125-017-4272-9 |
| Pubmed ID | |
| Authors |
Meghan F. Hogan, Rebecca L. Hull |
| Abstract |
The pancreatic islet is highly vascularised, with an extensive capillary network. In addition to providing nutrients and oxygen to islet endocrine cells and transporting hormones to the peripheral circulation, islet capillaries (comprised primarily of islet endothelial cells) are an important source of signals that enhance survival and function of the islet beta cell. In type 2 diabetes, and animal models thereof, evidence exists of morphological and functional abnormalities in these islet endothelial cells. In diabetes, islet capillaries are thickened, dilated and fragmented, and islet endothelial cells express markers of inflammation and activation. In vitro data suggest that this dysfunctional islet endothelial phenotype may contribute to impaired insulin release from the beta cell. This review examines potential candidate molecules that may mediate the positive effects of islet endothelial cells on beta cell survival and function under normal conditions. Further, it explores possible mechanisms underlying the development of islet endothelial dysfunction in diabetes and reviews therapeutic options for ameliorating this aspect of the islet lesion in type 2 diabetes. Finally, considerations regarding differences between human and rodent islet vasculature and the potentially unforeseen negative consequences of strategies to expand the islet vasculature, particularly under diabetic conditions, are discussed. |
X Demographics
The data shown below were collected from the profiles of 46 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 11 | 24% |
| United Kingdom | 3 | 7% |
| Germany | 3 | 7% |
| Australia | 2 | 4% |
| United States | 2 | 4% |
| Canada | 2 | 4% |
| France | 1 | 2% |
| Denmark | 1 | 2% |
| Finland | 1 | 2% |
| Other | 6 | 13% |
| Unknown | 14 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 27 | 59% |
| Scientists | 9 | 20% |
| Practitioners (doctors, other healthcare professionals) | 6 | 13% |
| Science communicators (journalists, bloggers, editors) | 4 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 104 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 28% |
| Researcher | 19 | 18% |
| Student > Master | 15 | 14% |
| Student > Bachelor | 6 | 6% |
| Student > Doctoral Student | 5 | 5% |
| Other | 9 | 8% |
| Unknown | 22 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 33 | 31% |
| Medicine and Dentistry | 10 | 9% |
| Agricultural and Biological Sciences | 9 | 8% |
| Engineering | 9 | 8% |
| Immunology and Microbiology | 5 | 5% |
| Other | 12 | 11% |
| Unknown | 28 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 July 2023.
All research outputs
#1,272,351
of 25,732,188 outputs
Outputs from Diabetologia
#684
of 5,376 outputs
Outputs of similar age
#24,822
of 325,801 outputs
Outputs of similar age from Diabetologia
#16
of 74 outputs
Altmetric has tracked 25,732,188 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,376 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.7. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,801 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.