| Title |
Pallidal stimulation for primary generalised dystonia: effect on cognition, mood and quality of life
|
|---|---|
| Published in |
Journal of Neurology, November 2013
|
| DOI | 10.1007/s00415-013-7161-2 |
| Pubmed ID | |
| Authors |
Marjan Jahanshahi, Mariam Torkamani, Mazda Beigi, Leonora Wilkinson, Donna Page, Laura Madeley, Kailash Bhatia, Marwan Hariz, Ludvic Zrinzo, Patricia Limousin, Diane Ruge, Stephen Tisch |
| Abstract |
We investigated the effect of pallidal deep brain stimulation (GPi-DBS) in dystonia on cognition, mood, and quality of life and also assessed if DYT1 gene status influenced cognitive outcome following GPi-DBS. Fourteen patients with primary generalized dystonia (PGD) were assessed, measuring their estimated premorbid and current IQ, memory for words and faces, and working memory, language, executive function, and sustained attention, one month before and one year or more after surgery. Changes in mood and behaviour and quality of life were also assessed. There was a significant improvement of dystonia with GPi-DBS (69 % improvement in Burke-Fahn-Marsden score, p < 0.0001). Performance on five cognitive tests either improved or declined at post-surgical follow-up. Calculation of a reliable change index suggested that deterioration in sustained attention on the PASAT was the only reliable change (worse after surgery) in cognition with GPi-DBS. DYT1 gene status did not influence cognitive outcome following GPi-DBS. Depression, anxiety and apathy were not significantly altered, and ratings of health status on the EQ5D remained unchanged. In our sample, GPi-DBS was only associated with an isolated deficit on a test of sustained attention, confirming that GPi-DBS in PGD is clinically effective and safe, without adverse effects on the main domains of cognitive function. The dissociation between GPi-DBS improving dystonia, but not having a significant positive impact on the patients' QoL, warrants further investigation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Belgium | 1 | <1% |
| Unknown | 114 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 16% |
| Student > Ph. D. Student | 17 | 15% |
| Student > Master | 13 | 11% |
| Student > Doctoral Student | 10 | 9% |
| Student > Bachelor | 7 | 6% |
| Other | 20 | 17% |
| Unknown | 30 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 27 | 23% |
| Medicine and Dentistry | 24 | 21% |
| Neuroscience | 13 | 11% |
| Computer Science | 3 | 3% |
| Biochemistry, Genetics and Molecular Biology | 3 | 3% |
| Other | 6 | 5% |
| Unknown | 40 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2013.
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#20,209,145
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Outputs from Journal of Neurology
#3,964
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#186,090
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Outputs of similar age from Journal of Neurology
#25
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