| Title |
Microbial response to environmental stresses: from fundamental mechanisms to practical applications
|
|---|---|
| Published in |
Applied Microbiology and Biotechnology, April 2017
|
| DOI | 10.1007/s00253-017-8264-y |
| Pubmed ID | |
| Authors |
Ningzi Guan, Jianghua Li, Hyun-dong Shin, Guocheng Du, Jian Chen, Long Liu |
| Abstract |
Environmental stresses are usually active during the process of microbial fermentation and have significant influence on microbial physiology. Microorganisms have developed a series of strategies to resist environmental stresses. For instance, they maintain the integrity and fluidity of cell membranes by modulating their structure and composition, and the permeability and activities of transporters are adjusted to control nutrient transport and ion exchange. Certain transcription factors are activated to enhance gene expression, and specific signal transduction pathways are induced to adapt to environmental changes. Besides, microbial cells also have well-established repair mechanisms that protect their macromolecules against damages inflicted by environmental stresses. Oxidative, hyperosmotic, thermal, acid, and organic solvent stresses are significant in microbial fermentation. In this review, we summarize the modus operandi by which these stresses act on cellular components, as well as the corresponding resistance mechanisms developed by microorganisms. Then, we discuss the applications of these stress resistance mechanisms on the production of industrially important chemicals. Finally, we prospect the application of systems biology and synthetic biology in the identification of resistant mechanisms and improvement of metabolic robustness of microorganisms in environmental stresses. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 196 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | <1% |
| Unknown | 195 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 39 | 20% |
| Student > Ph. D. Student | 29 | 15% |
| Student > Master | 23 | 12% |
| Researcher | 17 | 9% |
| Student > Doctoral Student | 10 | 5% |
| Other | 24 | 12% |
| Unknown | 54 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 57 | 29% |
| Biochemistry, Genetics and Molecular Biology | 35 | 18% |
| Immunology and Microbiology | 12 | 6% |
| Environmental Science | 6 | 3% |
| Veterinary Science and Veterinary Medicine | 5 | 3% |
| Other | 23 | 12% |
| Unknown | 58 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2018.
All research outputs
#18,922,529
of 24,119,703 outputs
Outputs from Applied Microbiology and Biotechnology
#6,246
of 8,034 outputs
Outputs of similar age
#226,779
of 313,599 outputs
Outputs of similar age from Applied Microbiology and Biotechnology
#60
of 100 outputs
Altmetric has tracked 24,119,703 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,034 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,599 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 100 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.