| Title |
Genotyping and Persistence of Candida albicans from Pregnant Women with Vulvovaginal Candidiasis
|
|---|---|
| Published in |
Mycopathologia, November 2016
|
| DOI | 10.1007/s11046-016-0095-3 |
| Pubmed ID | |
| Authors |
Cecilia V. Tapia, Germán Hermosilla, Paula Fortes, Claudio Alburquenque, Sergio Bucarey, Hugo Salinas, Paula I. Rodas, María Cristina Díaz, Fabien Magne |
| Abstract |
To study Candida albicans genotypes using RAPD and their susceptibility to fluconazole in healthy pregnant women and in vulvovaginal candidiasis (VVC) patients after topical treatment with clotrimazole. Vaginal swabs were collected at t = 0 and t = 1 (1 month later) in pregnant women (control group, n = 33), and before (t = 0), at 1 month (t = 1) and at 2 months (t = 2) after clotrimazole treatment in pregnant women with VVC. Candida albicans was isolated in 30% of healthy pregnant women and 80% of patients with VVC. A high genetic heterogeneity was observed in C. albicans genotypes between individuals. In patients with VVC, topical antifungal treatment with clotrimazole was clinically effective, but only in a 62% C. albicans was eradicated. In patients in which C. albicans was not eradicated, this microorganism persisted for 1 or 2 months after the antifungal treatment. The persistent colonies were not associated with a specific genotype, but they were associated with higher MICs in comparison with colonies isolated from the control group. Therapy with topical clotrimazole, despite a good clinical outcome, could not eradicate completely C. albicans allowing the persistence of genotypes, with higher MICs to fluconazole. More studies with higher number of patients are needed to validate this preliminary finding. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 3% |
| Unknown | 38 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 6 | 15% |
| Student > Bachelor | 4 | 10% |
| Student > Master | 4 | 10% |
| Researcher | 3 | 8% |
| Professor > Associate Professor | 3 | 8% |
| Other | 8 | 21% |
| Unknown | 11 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 21% |
| Biochemistry, Genetics and Molecular Biology | 4 | 10% |
| Agricultural and Biological Sciences | 3 | 8% |
| Immunology and Microbiology | 3 | 8% |
| Nursing and Health Professions | 2 | 5% |
| Other | 5 | 13% |
| Unknown | 14 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2017.
All research outputs
#18,541,268
of 22,963,381 outputs
Outputs from Mycopathologia
#782
of 1,079 outputs
Outputs of similar age
#303,870
of 415,808 outputs
Outputs of similar age from Mycopathologia
#8
of 13 outputs
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