| Title |
A multitasking Argonaute: exploring the many facets of C. elegans CSR-1
|
|---|---|
| Published in |
Chromosome Research, November 2013
|
| DOI | 10.1007/s10577-013-9383-7 |
| Pubmed ID | |
| Authors |
Christopher J. Wedeles, Monica Z. Wu, Julie M. Claycomb |
| Abstract |
While initial studies of small RNA-mediated gene regulatory pathways focused on the cytoplasmic functions of such pathways, identifying roles for Argonaute/small RNA pathways in modulating chromatin and organizing the genome has become a topic of intense research in recent years. Nuclear regulatory mechanisms for Argonaute/small RNA pathways appear to be widespread, in organisms ranging from plants to fission yeast, Caenorhabditis elegans to humans. As the effectors of small RNA-mediated gene regulatory pathways, Argonaute proteins guide the chromatin-directed activities of these pathways. Of particular interest is the C. elegans Argonaute, chromosome segregation and RNAi deficient (CSR-1), which has been implicated in such diverse functions as organizing the holocentromeres of worm chromosomes, modulating germline chromatin, protecting the genome from foreign nucleic acid, regulating histone levels, executing RNAi, and inhibiting translation in conjunction with Pumilio proteins. CSR-1 interacts with small RNAs known as 22G-RNAs, which have complementarity to 25 % of the protein coding genes. This peculiar Argonaute is the only essential C. elegans Argonaute out of 24 family members in total. Here, we summarize the current understanding of CSR-1 functions in the worm, with emphasis on the chromatin-directed activities of this ever-intriguing Argonaute. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| United Kingdom | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Germany | 1 | 2% |
| Unknown | 62 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 26% |
| Researcher | 14 | 22% |
| Student > Doctoral Student | 6 | 9% |
| Student > Bachelor | 5 | 8% |
| Student > Master | 5 | 8% |
| Other | 9 | 14% |
| Unknown | 9 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 35 | 54% |
| Biochemistry, Genetics and Molecular Biology | 17 | 26% |
| Economics, Econometrics and Finance | 1 | 2% |
| Earth and Planetary Sciences | 1 | 2% |
| Medicine and Dentistry | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 7 | 11% |
Attention Score in Context
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All research outputs
#17,702,587
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Outputs from Chromosome Research
#392
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Outputs of similar age from Chromosome Research
#5
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