| Title |
Drug/diet synergy for managing malignant astrocytoma in mice: 2-deoxy-D-glucose and the restricted ketogenic diet
|
|---|---|
| Published in |
Nutrition & Metabolism, November 2008
|
| DOI | 10.1186/1743-7075-5-33 |
| Pubmed ID | |
| Authors |
Jeremy Marsh, Purna Mukherjee, Thomas N Seyfried |
| Abstract |
Astrocytomas are largely dependent on glycolysis to satisfy their bioenergetic requirements for growth and survival. Therapies that target glycolysis can potentially manage astrocytoma growth and progression. Dietary restriction of the high fat/low carbohydrate ketogenic diet (KD-R) reduces glycolysis and is effective in managing experimental mouse and human astrocytomas. The non-metabolizable glucose analogue, 2-deoxy-D-glucose (2-DG), is a potent glycolytic inhibitor that can mimic effects of energy restriction both in vitro and in vivo, but can also produce adverse effects when administered at doses greater than 200 mg/kg. The goal here was to determine if low doses of 2-DG could act synergistically with the KD-R to better manage growth of the CT-2A malignant mouse astrocytoma. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Israel | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 72 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 14% |
| Student > Ph. D. Student | 9 | 12% |
| Student > Bachelor | 9 | 12% |
| Student > Postgraduate | 8 | 11% |
| Researcher | 7 | 9% |
| Other | 12 | 16% |
| Unknown | 19 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 24% |
| Agricultural and Biological Sciences | 15 | 20% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Chemistry | 3 | 4% |
| Nursing and Health Professions | 3 | 4% |
| Other | 8 | 11% |
| Unknown | 23 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2017.
All research outputs
#13,901,154
of 22,729,647 outputs
Outputs from Nutrition & Metabolism
#578
of 944 outputs
Outputs of similar age
#135,853
of 165,168 outputs
Outputs of similar age from Nutrition & Metabolism
#17
of 23 outputs
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