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X Demographics
Mendeley readers
Attention Score in Context
| Title |
L1 retrotransposons, cancer stem cells and oncogenesis
|
|---|---|
| Published in |
FEBS Journal, November 2013
|
| DOI | 10.1111/febs.12601 |
| Pubmed ID | |
| Authors |
Patricia E. Carreira, Sandra R. Richardson, Geoffrey J. Faulkner |
| Abstract |
Retrotransposons have played a central role in human genome evolution. The accumulation of heritable L1, Alu and SVA retrotransposon insertions continues to generate structural variation within and between populations, and can result in spontaneous genetic disease. Recent works have reported somatic L1 retrotransposition in tumours, which in some cases may contribute to oncogenesis. Intriguingly, L1 mobilization appears to occur almost exclusively in cancers of epithelial cell origin. In this review, we discuss how L1 retrotransposition could potentially trigger neoplastic transformation, based on the established correlation between L1 activity and cellular plasticity, and the proven capacity of L1-mediated insertional mutagenesis to decisively alter gene expression and functional output. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 40% |
| Canada | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 2% |
| Iran, Islamic Republic of | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 122 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 34 | 27% |
| Student > Ph. D. Student | 30 | 24% |
| Student > Bachelor | 13 | 10% |
| Student > Master | 12 | 9% |
| Professor > Associate Professor | 6 | 5% |
| Other | 17 | 13% |
| Unknown | 15 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 53 | 42% |
| Biochemistry, Genetics and Molecular Biology | 33 | 26% |
| Medicine and Dentistry | 9 | 7% |
| Computer Science | 4 | 3% |
| Nursing and Health Professions | 2 | 2% |
| Other | 6 | 5% |
| Unknown | 20 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2023.
All research outputs
#6,495,301
of 25,371,288 outputs
Outputs from FEBS Journal
#3,519
of 12,259 outputs
Outputs of similar age
#69,473
of 320,115 outputs
Outputs of similar age from FEBS Journal
#11
of 129 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 12,259 research outputs from this source. They receive a mean Attention Score of 4.8. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,115 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 129 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.