Title |
Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging
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Published in |
Neurobiology of Aging, May 2010
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DOI | 10.1016/j.neurobiolaging.2010.04.007 |
Pubmed ID | |
Authors |
Christopher C. Rowe, Kathryn A. Ellis, Miroslava Rimajova, Pierrick Bourgeat, Kerryn E. Pike, Gareth Jones, Jurgen Fripp, Henri Tochon-Danguy, Laurence Morandeau, Graeme O'Keefe, Roger Price, Parnesh Raniga, Peter Robins, Oscar Acosta, Nat Lenzo, Cassandra Szoeke, Olivier Salvado, Richard Head, Ralph Martins, Colin L. Masters, David Ames, Victor L. Villemagne |
Abstract |
The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging, a participant of the worldwide Alzheimer's Disease Neuroimaging Initiative (ADNI), performed (11)C-Pittsburgh Compound B (PiB) scans in 177 healthy controls (HC), 57 mild cognitive impairment (MCI) subjects, and 53 mild Alzheimer's disease (AD) patients. High PiB binding was present in 33% of HC (49% in ApoE-epsilon4 carriers vs 21% in noncarriers) and increased with age, most strongly in epsilon4 carriers. 18% of HC aged 60-69 had high PiB binding rising to 65% in those over 80 years. Subjective memory complaint was only associated with elevated PiB binding in epsilon4 carriers. There was no correlation with cognition in HC or MCI. PiB binding in AD was unrelated to age, hippocampal volume or memory. Beta-amyloid (Abeta) deposition seems almost inevitable with advanced age, amyloid burden is similar at all ages in AD, and secondary factors or downstream events appear to play a more direct role than total beta amyloid burden in hippocampal atrophy and cognitive decline. |
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Geographical breakdown
Country | Count | As % |
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United States | 9 | 2% |
United Kingdom | 2 | <1% |
Germany | 1 | <1% |
Czechia | 1 | <1% |
Netherlands | 1 | <1% |
Denmark | 1 | <1% |
Italy | 1 | <1% |
Unknown | 498 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 93 | 18% |
Researcher | 87 | 17% |
Student > Master | 61 | 12% |
Student > Bachelor | 38 | 7% |
Student > Doctoral Student | 37 | 7% |
Other | 96 | 19% |
Unknown | 102 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 101 | 20% |
Neuroscience | 83 | 16% |
Psychology | 62 | 12% |
Agricultural and Biological Sciences | 44 | 9% |
Biochemistry, Genetics and Molecular Biology | 23 | 4% |
Other | 77 | 15% |
Unknown | 124 | 24% |